About the Project
RNA Pol II transcription and DNA replication are the two essential processes that use the DNA in our cells as a substrate. However, DNA can be engaged only by one of these processes at any given time, and when transcription impairs DNA replication it can induce DNA damage and genome instability. We have shown that transcription activity is transiently reduced to support the replication of genes. We have also identified two separate mechanisms that cells use to regulate transcription activity,…
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