inflammasome activation, complement activity and immunometabolic responses. Inter-individual variability will be mapped to define immune-response archetypes associated with protective, exaggerated or dysregulated responses. The project will then investigate whether these immune states can be selectively reprogrammed using small molecules and vaccine-relevant stimuli. A major innovation is the concept of sustained viral resilience, where transient modulation of innate pathways induces durable antiviral protection through metabolic and epigenetic mechanisms.

The work has direct applications in vaccine development, therapeutic design and national preparedness for emerging infectious diseases, with collaboration across the University of Liverpool, UK Health Security Agency (UKHSA) and Defence Science and Technology Laboratory (Dstl).

inflammasome activation, complement activity and immunometabolic responses. Inter-individual variability will be mapped to define immune-response archetypes associated with protective, exaggerated or dysregulated responses. The project will then investigate whether these immune states can be selectively reprogrammed using small molecules and vaccine-relevant stimuli. A major innovation is the concept of sustained viral resilience, where transient modulation of innate pathways induces durable antiviral protection through metabolic and epigenetic mechanisms.

The work has direct applications in vaccine development, therapeutic design and national preparedness for emerging infectious diseases, with collaboration across the University of Liverpool, UK Health Security Agency (UKHSA) and Defence Science and Technology Laboratory (Dstl).