About the Project

A three-year PhD studentship funded by Cure DHDDS is available from 1 October 2026, in the Translational Omics Research Group at the UCL Great Ormond Street Institute of Child Health.

This project will define how impaired dolichol biosynthesis disrupts glycosylation, protein handling and cellular quality control in DHDDS deficiency. By measuring these processes dynamically with stable isotope tracers and mass spectrometry, the study aims to convert a poorly understood rare disease into a measurable pathway for biomarker discovery, functional diagnostics and therapeutic target identification.

Background

DHDDS deficiency is a rare and devastating congenital disorder of glycosylation. It affects dolichol biosynthesis, a core biochemical pathway required for normal protein glycosylation. Despite this, patients often do not show the classical transferrin isoelectric focusing pattern that usually reveals defective glycoprotein synthesis in CDG.

Hypothesis and aims

We hypothesise that DHDDS deficiency causes a dynamic failure of dolichol driven glycosylation and protein quality control that is not fully captured by conventional CDG testing.

Research outputs

The project will deliver a stable isotope based cellular model of DHDDS deficiency that can measure dolichol flux, glycoprotein synthesis, protein folding, trafficking and degradation in real time.

About you

Applicants should have a keen research interest in metabolism and neurodegeneration but especially in the omic techniques of proteomics and lipidomics. Applicants should have a minimum of an upper second-class UK Bachelor’s degree and/or a Master’s degree (preferably with a merit or distinction) in a biological sciences preferably biochemistry.

What we offer

This studentship provides a starting stipend of £23,805 per annum and covers the cost of Home and Overseas tuition fees.

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Omics and Organoid Models to Reveal DHDDS Disease Mechanisms

University College London

UCL Main Campus, Gower Street, London, UK

About the Project

This is a Preview Listing…

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About the Project

This is a Preview Listing…

Related Jobs

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Grants to USA Entities for Advanced Materials Research

Grants to USA, Canada, and International Nonprofits to Support Children With Cancer

Fellowships to USA, Canada, and United Kingdom Researchers for AI Policy and Economics Research

Fellowships to USA, Canada, and United Kingdom Researchers and Engineers for RL Systems Research

Fellowships to USA, Canada, and United Kingdom Engineers and Researchers for ML System Research

Fellowships to USA, Canada, and United Kingdom Researchers for AI Security Research

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Omics and Organoid Models to Reveal DHDDS Disease Mechanisms

University College London