Rate My Professor Yuehai Ke

Professor Yuehai Ke is a Professor, Ph.D. holder, and Doctoral Supervisor in the School of Medicine at Zhejiang University. He currently serves as the Dean of the Zhejiang University-University of Edinburgh Institute (ZJE) and as Principal Investigator in the Department of Pathology and Pathophysiology, Zhejiang University School of Medicine. Previously recognized in international collaborations such as with the University of Toronto's Department of Molecular Genetics, Ke's career highlights his leadership in medical education and research administration. His research specializations encompass molecular cell biology and lung immunology, with a focus on molecular medicine, lung tissue injury and repair mechanisms, cross-organ regulation, regional immunity, inflammatory and cancer microenvironments, complex disease phenotype studies, and AI-enabled investigations into regional metabolism and signal modifications. Ke has significantly contributed to understanding cellular signaling pathways, such as Shp2 phosphatase roles in macrophage activation, pulmonary fibrosis, epithelial necroptosis, and inflammasome regulation in lung diseases.

Ke has earned prestigious honors including selection as a national talent project winner, national young and middle-aged expert with outstanding contributions, new century talent of the Ministry of Education, leading talent in Zhejiang Province's talent plan, and member of the Zhejiang 151 project. He has presided over major funding initiatives, such as the 973 Program of the Ministry of Science and Technology, the Protein Major project, a national key R&D program, and five National Natural Science Foundation of China projects (both key and general). His key publications include 'Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages' (Nature Communications, 2021), 'Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome' (Immunity, 2016), 'Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis' (Journal of Immunology, 2014), and works on Shp2 in neural stem cells (Molecular and Cellular Biology, 2007) and thymocyte signaling (Journal of Immunology, 2006). Additional representative papers appear in Science, Cell Research, Journal of Experimental Medicine, Journal of Extracellular Vesicles, and Cellular & Molecular Immunology. Through these efforts, Ke has influenced advancements in pulmonology, immunology, and translational medicine.