Encourages students to think critically.
Xihua Lian earned her Doctor of Philosophy from the University of Otago in 2023, conducting her research in the Department of Pathology and Biomedical Science at the University of Otago, Christchurch, as part of the Inflammation Research Group. Her doctoral thesis, titled 'Novel monoclonal antibodies 1D2 and 4E4 facilitate the diagnosis and treatment of invasive aspergillosis,' was supervised by Madhav Bhatia, Aamir Raja, Steve Chambers, and John Lewis. Lian's work centers on developing monoclonal antibodies to detect and inhibit clinically important Aspergillus species, addressing a significant challenge in managing invasive fungal infections, particularly in immunocompromised patients. Prior to her PhD, she held an MMed position and contributed to ultrasound research, including studies on fetal thorax measurements using two- and three-dimensional ultrasound techniques, lung ultrasound for differentiating COVID-19 pneumonia from community-acquired pneumonia, and point-of-care ultrasound for pulmonary edema assessment, affiliated with institutions in China such as the Second Affiliated Hospital of Fujian Medical University.
Lian has been recognized with several honors for her contributions. In 2023, she received the McGee Fellowship, valued at $20,000, to further her research on monoclonal antibodies as diagnostic and therapeutic tools for invasive aspergillosis in the context of respiratory disorders. She was also a joint winner of the Department of Pathology and Biomedical Science's 2023 Best Early Career Paper Prize for her publication 'A novel monoclonal antibody 1D2 that broadly inhibits clinically-important Aspergillus species' in the Journal of Fungi (2022, volume 8, issue 9). Additionally, the 2021 Professor Sandy Smith Memorial Scholarship supported her project on applying MARS Spectral CT for diagnosing fungal infections. Key publications from her Otago research include 'Novel Monoclonal Antibodies 1D2 and 4E4 Against Aspergillus spp.' (Journal of Fungi, 2024), 'Monoclonal Antibodies and Invasive Aspergillosis: Diagnostic, Prognostic, and Therapeutic Implications' (Journal of Fungi, 2022), and 'Two Monoclonal Antibodies That Specifically Recognize Cell Wall Galactosaminogalactan in Aspergillus fumigatus' (International Journal of Molecular Sciences, 2022). Lian has presented her findings at the University of Otago Christchurch Research Seminar Series and the Dunedin BSE Course, contributing to advancements in fungal diagnostics and inflammation research.

Photo by Osarugue Igbinoba on Unsplash
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