Professor Mark Bathe is a Professor of Biological Engineering in the Department of Biological Engineering at the Massachusetts Institute of Technology (MIT). He received his B.Sc. in Mechanical Engineering from MIT in 1998, M.Sc. in Mechanical Engineering in 2001, and Ph.D. in Mechanical Engineering in 2004. He then served as an Alexander von Humboldt Postdoctoral Fellow at the University of Munich from 2006 to 2008. In 2009, Bathe joined the MIT faculty as an Assistant Professor in Biological Engineering, was promoted to Associate Professor in 2013 and granted tenure in 2016, and became a full Professor in 2020. He has held additional appointments as an Associate Member of the Broad Institute of MIT and Harvard since 2012, Member of the Harvard Medical School Initiative for RNA Medicine since 2021, and Director of the MIT New Engineering Education Transformation from 2022 to 2023. Bathe is also a co-founder and Scientific Advisory Board member of Cache DNA, Inc., and Kano Therapeutics, Inc., since 2022.

Bathe's research centers on nucleic acid nanotechnology, utilizing DNA and RNA to create programmable nanoscale materials for revolutionary applications in therapeutics, vaccines, quantum computing, sensing, and molecular data storage. His group engineers targeted in vivo delivery vehicles for therapeutic nucleic acids such as siRNA, mRNA, and CRISPR components to address genetic diseases and cancer. Notable publications include "A primer to scaffolded DNA origami" in Nature Methods (2011), "Designer nanoscale DNA assemblies programmed from the top down" in Science (2016), "Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures" in Nucleic Acids Research (2012), "Role of nanoscale antigen organization on B-cell activation probed using DNA origami" in Nature Nanotechnology (2020), and "Casting inorganic structures with DNA molds" in Science (2014). His work has been cited over 10,000 times according to Google Scholar. Among his honors are the MIT Class of 1960 Fellowship (2019), Joy Cappel Young Investigator Award (2015), Samuel A. Goldblith Career Development Professorship (2009), and National Defense Science and Engineering Graduate Fellowship (2001). Bathe has contributed to MIT governance as Chair of the Committee on Student Life (2017–2019) and served on the Editorial Board of Scientific Reports (2019–2021).

Professional Email: mbathe@mit.edu