Rate My Professor Yang Gao

Yang Gao is an Assistant Professor in the Department of Cancer Biology and Genetics at The Ohio State University College of Medicine. In the field of Medicine, his research centers on the tumor ecosystem, with a particular focus on the heterogeneity of the immune landscape within tumors, the mechanisms of therapeutic resistance, and the tumor-host interactions that drive cancer metastasis. He specifically investigates myeloid cell heterogeneity in immunotherapy resistance, the bone microenvironment's role in breast cancer bone metastasis, neutrophil interferon-stimulated genes in the tumor immune microenvironment and their impact on immunotherapy response, and the immunosuppressive ecosystems that enable breast cancer metastasis to distant organs such as bone, lung, liver, and brain. To explore these areas, Gao utilizes advanced methodologies including spatial transcriptomics, single-cell multi-omics, tumor immunology techniques, and in vivo genetically engineered mouse models. His work aims to uncover the fundamental reasons for treatment resistance and distant recurrence in solid tumors, especially breast cancer.