Rate My Professor William Gray

Gray's research specializations include clinical studies in epilepsy, hippocampal function, learning, and memory, utilizing advanced imaging techniques such as intracranial EEG recordings, white matter fibre tractography, grey matter microstructure analysis, and fMRI to elucidate seizure origins and cognitive impairments in epilepsy patients. He employs human brain tissue and cerebrospinal fluid from epilepsy, tumour, and head injury surgeries for translational research, including 3D ex vivo culturing of human brain tissue to study brain function, disease mechanisms, and cell transplantation for repair. As a surgeon-neuroscientist, his work emphasizes brain repair through cell replacement using endogenous or transplanted neural precursor cells and cellular reprogramming via gene or RNA therapies. He is UK Chief Investigator for the uniQure AMT-130 gene therapy trial for Huntington’s disease and Principal Investigator for gene therapy trials in frontotemporal dementia (Aviadobio) and Parkinson’s disease (AskBio). Key publications include 'Translating cell therapies for neurodegenerative diseases' (Brain, 2022), 'Cell therapy for Huntington's disease: learning from failure' (Movement Disorders, 2021), 'Do foetal transplant studies continue to be justified in Huntington's disease?' (Neuronal Signaling, 2021), and contributions to epilepsy surgery outcomes and neuroimaging studies such as 'Predictive models for starting antiseizure medication withdrawal following epilepsy surgery in adults' (Brain, 2023). His contributions advance clinical translation of neurotherapeutics, influencing early-phase trials for neurodegenerative diseases.