Rate My Professor Stephanie Bozonet

Bozonet's research interests centre on redox biology and the effects of oxidants on cell systems. She investigates the bioavailability of ascorbate (vitamin C), an essential enzyme co-factor and biological antioxidant, and its roles in the immune system. Her work explores oxidants' contributions to innate immunity, inflammation, and disease, noting that immune cells such as neutrophils produce oxidants to fight infections but may also damage host cells and tissues. Currently, she is characterising the effects of oxidants on the regulation of cell death pathways. Key publications include Pullar et al. (2025), "Improved human skin vitamin C levels and skin function following dietary intake of kiwifruit," Journal of Investigative Dermatology; Peskin, Magon, and Bozonet (2025), "High-dose vitamin C blocks HOCl production by myeloperoxidase: A potential therapeutic strategy," Biochemical & Biophysical Research Communications; Bozonet et al. (2015), "Restoring physiological levels of ascorbate slows tumor growth and modulates hypoxia signalling in cancer cells," Cancer Medicine; and Bozonet et al. (2021), "Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C: Implications for Sepsis Management," Antioxidants. Her contributions have advanced knowledge on vitamin C's potential in treating cancer, sepsis, and inflammatory diseases.