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Rate My Professor Safina Gadeock

University of Otago

Ratings & reviews

5.04/23/2026

Brings enthusiasm and expertise to class.

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About Safina

Dr. Safina Gadeock serves as a Research Fellow in the Department of Microbiology and Immunology within the University of Otago's Division of Health Sciences. She earned her PhD from the University of Otago, with her doctoral thesis titled "Human Colonic Organoids: An Epithelial Barrier Model of Crohn's Disease." Her research centers on epithelial and immune cell dynamics in the context of Inflammatory Bowel Disease (IBD). Employing patient-derived 3D intestinal organoids, Gadeock examines epithelial stem cell injury, repair mechanisms, and barrier function. Her studies have identified an inherent stem cell-dependent developmental defect in the epithelium and barrier integrity of IBD patients. Furthermore, she has elucidated novel roles for TNF signaling through TNFR1 in the specification and function of colonic mesenchymal cells, the maintenance of the epithelial stem cell niche, and the regulation of deep crypt secretory cells. Current investigations focus on Type I interferon targets as predictors of clinical non-response to anti-TNF therapies in IBD patients and their influence on epithelial innate responses to commensal metabolites like butyrate.