Rate My Professor Roland Chung

Dr. Roland Chung serves as a Lecturer in Pharmacy and Pharmaceutical Sciences Education within the Faculty of Pharmacy and Pharmaceutical Sciences at Monash University. He is affiliated with the Medicinal Chemistry group at the Monash Institute of Pharmaceutical Sciences. His research focuses on medicinal chemistry, particularly the structural biology and function of enzymes including aldose reductase-like protein AKR1B14, aldehyde reductase, and L-xylulose reductase. Chung utilizes X-ray crystallography, site-directed mutagenesis, molecular modelling, and analysis of binding constants to study inhibitor binding, coenzyme interactions, and critical disulfide bonds in enzyme active sites. This work contributes to understanding mechanisms relevant to drug development and supports SDG 3: Good Health and Well-being.

With 31 research outputs dating back to 1986, Dr. Chung's key publications include 'Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis' (Bioorganic and Medicinal Chemistry Letters, 2011); 'Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor' (European Journal of Medicinal Chemistry, 2010); 'Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase' (Bioorganic & Medicinal Chemistry, 2009); 'Crystallization and preliminary X-ray analysis of a rat aldose reductase-like protein (AKR1B14)' (Acta Crystallographica Section F: Structural Biology Communications, 2009); and 'Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase' (Cellular and Molecular Life Sciences, 2009). In education, he coordinates BPS1021 (Medicinal chemistry 1: Structure), BPS1022 (Medicinal chemistry 2: Reactivity and biomolecules), and PHR1222 (How medicines work 4: Medicinal chemistry). He has led Collier Charitable Fund projects for research equipment in 2003 and 2009 and was a member of the Royal Australian Chemical Institute from 2013 to 2020.