Rate My Professor Philip Eaton

Eaton’s research examines how oxidants function as regulatory signals by reacting with select cysteine thiol side chains on proteins, leading to oxidative post-translational modifications that alter protein function for adaptation and homeostasis during cardiovascular health and disease. His team identifies thiol-based redox sensor proteins and develops electrophilic drugs that target precise redox-regulated cysteines for therapeutic benefit against cardiovascular conditions. In 2023, he was awarded a €2.5 million European Research Council Advanced Grant. Eaton has published extensively in high-impact journals, including “Cysteine Redox Sensor in PKGIα Enables Oxidant-Induced Activation” (Science, 2007), “Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability To Cause Aortopathy” (JACC: Basic to Translational Science, 2026), “A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective” (Redox Biology, 2025), and “Protein kinase GIα oxidation negatively regulates antibody production by B cells” (Redox Biology, 2025). He contributes to teaching as an MBBS SSC supervisor, BHF MRes lecturer, and PhD supervisor and examiner, influencing the next generation of cardiovascular researchers.