Paul Williams

Associate Professor Paul F. Williams, PhD, serves as an Associate Professor in the Department of Endocrinology within the Sydney Medical School at the University of Sydney, a position he has held as part of his long-standing affiliation with the Central Clinical School since March 1972. Concurrently, since April 1972, he has been Principal Hospital Scientist and Laboratory Director at the Department of Endocrinology Pathology Services, Royal Prince Alfred Hospital, Camperdown, Australia. He also held a professorial appointment in the Department of Internal Medicine at Stony Brook University Hospital, United States, from January 1992 to April 1993. Williams leads the Paul F. Williams Lab, focusing on translational research in endocrinology.

His research specializations include diabetes and its complications, obesity, adipose tissue metabolism, insulin resistance, non-alcoholic steatohepatitis (NASH), gestational diabetes, pre-eclampsia, thyroid autoimmunity, vitamin D assays, liver fibrosis, and monocyte phenotypes in wound healing. Williams investigates the profibrotic and proinflammatory effects of TGFβ1 in adipocytes, metabolic impacts of sustained high-fat diets on white and brown adipose tissue, exercise training protocols such as constant-moderate endurance and high-intensity interval training on heart and adipose adiponectin levels, point-of-care testing for HbA1c, renal function, and lipids in remote regions, and first-trimester screening models for pregnancy complications. With 94 publications cited 2,916 times, key works encompass "The Effect of TGFβ1 in Adipocyte on Inflammatory and Fibrotic Markers at Different Stages of Adipocyte Differentiation" (2022), "The Effect of a Sustained High-Fat Diet on the Metabolism of White and Brown Adipose Tissue and Its Impact on Insulin Resistance: A Selected Time Point Cross-Sectional Study" (2021), "Exercise induces favorable metabolic changes in white adipose tissue preventing high-fat diet obesity" (2021), "The effect of TGFβ1 on thermogenic markers is dependent on the degree of adipocyte differentiation" (2020), "Constant-moderate versus high-intensity interval training on heart adiponectin levels in high-fat fed mice" (2020), and "Liver enzyme profile and progression in association with thyroid autoimmunity in Graves' disease" (2019). His contributions advance understanding and management of metabolic disorders.

Professional Email: paul.williams@sydney.edu.au