Rate My Professor Nicholas Tomkinson

Professor Tomkinson's research specializes in the development of synthetic methodologies for bond construction, adhering to three key principles: reactions that proceed at room temperature, tolerance to moisture and air, and the use of bench-stable catalysts or reagents that can be prepared in three synthetic steps or fewer. His contributions span chemical biology, including the design of chemical probes for real-time Raman imaging, stimulated Raman scattering microscopy for drug discovery, and covalent targeting in proteins. Notable publications include "A chemical probe for prostate-specific membrane antigen for real-time Raman imaging of prostate cancer cells" in ACS Sensors (2026), "BET isoform selectivity through diverse linkers for bivalent inhibitors: GSK785, a BRD2/4-selective bivalent BET inhibitor" in the Journal of Medicinal Chemistry (2026), "Emerging applications of stimulated Raman scattering microscopy for medicinal chemistry and drug discovery" in Chemical Society Reviews (2025), and "Label-free screening of drug-induced liver injury using stimulated Raman scattering microscopy and spectral phasor analysis" in Analytical Chemistry (2024). He has led or co-investigated in 39 projects, including major initiatives like the BBSRC-funded analysis of S-acylation dynamics in cell physiology (2025-2030) and collaborations with GlaxoSmithKline. His work is highly cited, with over 6,130 citations on Google Scholar, influencing synthetic organic chemistry and interdisciplinary applications in biomedicine. Additionally, he has served as an external PhD examiner and hosted international visiting researchers.