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Dr. Nathalie Bérubé is a Professor (Basic Scientist in Paediatrics) in the Department of Anatomy and Cell Biology at the Schulich School of Medicine & Dentistry, Western University. She holds cross-appointments in Paediatrics and previously in Biochemistry. Dr. Bérubé completed her Ph.D. in Biochemistry at the University of Ottawa in 1996. She then completed postdoctoral training at Baylor College of Medicine in Houston as a Doris and Curtis Hankamer Postdoctoral Fellow and subsequently at the Ottawa Health Research Institute as a CIHR Research Fellow. She joined the University of Western Ontario in September 2003.
Dr. Bérubé’s research centers on the epigenetic regulation of brain development through the study of proteins that dictate chromatin structure, cell cycle progression, and neuronal function. Her work on ATRX gain- and loss-of-function mouse models has advanced understanding of the role of chromatin remodelling complexes in neuronal survival and differentiation, with a focus on the ATRX protein as an epigenetic regulator of gene transcription by modulating chromatin accessibility and DNA methylation. She is the recipient of a CIHR New Investigator Award and has received federal funding, including over $1 million from CIHR for research on improving memory in children with intellectual disabilities. Her professional email address is publicly listed on official university sources.
Western University researchers demonstrate perinatal ATRX ablation in microglia causes transient dysregulation but spares cognitive and social functions, highlighting neural resilience.
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