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Rate My Professor Michelle Mondoux

College of the Holy Cross

Ratings & reviews

4.08/20/2025

Fosters a love for lifelong learning.

5.04/30/2025

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About Michelle

Michelle Mondoux is an Associate Professor of Biology at the College of the Holy Cross. She earned her Ph.D. from Princeton University. Her research employs the nematode Caenorhabditis elegans as a model to explore molecular, cellular, and genetic responses to nutrient stress, with a focus on high-glucose diets. Mondoux investigates how excess nutrition influences fertility, lifespan, and other processes. Central to her studies are genes such as the insulin receptor (daf-2), O-GlcNAc transferase (ogt-1), and O-GlcNAcase (oga-1), which prove essential for the glucose stress response. Her lab employs genetic, molecular biology, and cell biology techniques to determine how these genes regulate fertility under glucose stress and whether maternal effects persist across generations. Additionally, unbiased genetic screens have identified over 100 candidate genes linked to aging, immunity, protein trafficking, and mitochondrial function that modulate insulin signaling during glucose stress.

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