
Washington University in St. Louis
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Marcus E. Raichle, MD, is the Alan A. and Edith L. Wolff Distinguished Professor of Medicine and Professor of Radiology, Neurology, Neuroscience, Psychological & Brain Sciences, and Biomedical Engineering at Washington University School of Medicine in St. Louis. He earned his bachelor's degree in 1959 and medical degree in 1964 from the University of Washington, completed a residency in internal medicine at Johns Hopkins School of Medicine, and a residency in neurology at Cornell University Medical College. After serving as a flight surgeon in the U.S. Air Force during the Vietnam War era, he joined the Washington University faculty more than 50 years ago with joint appointments in neurology and radiology, and previously served as head of the Neuroimaging Labs Research Center. Raichle is affiliated with the Philosophy-Neuroscience-Psychology program, the Hope Center for Neurological Disorders, and the Office of Neuroscience Research.
Raichle's research centers on functional brain imaging using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to examine human brain organization and function in health and disease. Key areas include studies of normal human brain function, the biological origins of functional brain imaging signals, systems underlying cognitive and emotional processes, and brain alterations in psychiatric conditions such as depression and anxiety. He relates changes in blood flow and metabolism to cellular activity. Pioneering contributions include the first integrated strategy for designing, executing, and interpreting functional brain images; demonstration that blood flow and glucose utilization change more than oxygen consumption during brain activation, foundational to fMRI; and discovery of the default mode network, a fronto-parietal system prominent during rest, revealing the brain's intrinsic organization. Seminal publications comprise "A default mode of brain function" (2001), "The human brain is intrinsically organized into dynamic, anticorrelated functional networks" (2005), "Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging" (2007), "The brain's default mode network" (2015), and "The Brain's Dark Energy" (2006). Raichle has received the 2014 Kavli Prize in Neuroscience, 2008 Ralph W. Gerard Prize in Neuroscience, 2001 Grawemeyer Award for Psychology, 2011 MetLife Foundation Award for Medical Research, and 2011 Lifetime Achievement Award from the International Society for Cerebral Blood Flow and Metabolism, among others. A member of the National Academy of Sciences, National Academy of Medicine, and American Academy of Arts and Sciences, he serves on the editorial board of Proceedings of the National Academy of Sciences. His work has revolutionized neuroimaging and insights into brain function, profoundly impacting neuroscience and psychology.
Professional Email: mraichle@wustl.edu