Rate My Professor Lasagna Reeves

Lasagna-Reeves' research centers on the role of tau protein in Alzheimer’s disease and related dementias, including tau oligomer formation, propagation, and synaptic toxicity. His lab identified Bassoon as a key mediator of tau-seed propagation and neurotoxicity, suggesting therapeutic strategies via its downregulation. Notable publications include “Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice” (Molecular Neurodegeneration, 2011), “Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau” (Scientific Reports, 2012), “Identification of oligomers at early stages of tau aggregation in Alzheimer’s disease” (FASEB Journal, 2012), “Molecular mechanisms of amyloid oligomers toxicity” (Journal of Alzheimer’s Disease, 2012), and “Bassoon contributes to tau-seed propagation and neurotoxicity” (Nature Neuroscience, 2022). His work earned the 2024 Rainwater Prize for Innovative Early-Career Scientist ($200,000 award), the 2023 Inge Grundke-Iqbal Award for Alzheimer’s Research, and recognition for the most impactful Alzheimer’s study (2022). These contributions have advanced insights into tau pathology mechanisms and potential interventions.