Rate My Professor Lars Fugger

Professor Fugger's research focuses on translational studies in multiple sclerosis (MS), a chronic inflammatory and degenerative disease of the central nervous system. His group elucidates the molecular basis of MHC gene associations with MS susceptibility, their interactions with environmental factors like viruses, and the mechanisms by which associated inflammation drives neurodegeneration, leading to long-term patient disability. Adopting a multidisciplinary approach through extensive local and international collaborations, the team emphasizes translational medicine, integrating basic scientists and clinicians. Notable publications include 'Elevated genetic risk for multiple sclerosis emerged in steppe pastoralists' (Barrie et al., Nature, 2024), revealing evolutionary origins of MS risk via ancient DNA analysis; 'Immune perturbation by the ileal microbiota in multiple sclerosis' (Jensen and Fugger, PNAS, 2025); 'A repair pathway lost in multiple sclerosis provides a new drug opportunity' (Jensen et al., Nature Immunology, 2024); and 'The spatiotemporal distribution of human pathogens in ancient Eurasia' (Sikora et al., Nature, 2025). His influential work has advanced understanding of MS pathogenesis and potential therapies. In recognition of his contributions, he was knighted by the Queen of Denmark in 2011. Fugger has shared insights through University of Oxford podcasts on MS and co-hosts the Oxford Neuroinflammation Conference.