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Rate My Professor Kienan Savage

The Queen's University Belfast

Ratings & reviews

4.08/20/2025

A master at fostering understanding.

5.04/30/2025

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About Kienan

Professor Kienan Savage is Professor of Molecular Oncology in the School of Medicine, Dentistry and Biomedical Sciences at Queen's University Belfast, affiliated with the Patrick G. Johnston Centre for Cancer Research. He leads the DNA Damage Response research group, focusing on the cellular DNA damage response and repair pathways. His work examines how defects in these systems contribute to cancer development, progression, and response to therapy, with particular emphasis on breast cancer, inherited breast cancer, and blood cancers such as myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Recent investigations link DNA damage response deficiencies, including those in BRCA1/2-mutant cells, to activation of the cGAS/STING innate immune pathway. This research aims to optimize combination therapies, including immune checkpoint blockade, by exploiting these immune responses in solid tumors and haematological malignancies. Savage's group also explores spliceosome mutations like SF3B1 and their implications for immune activation and therapy sensitivity.

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