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About Janine
Janine Post is an Associate Professor in the Department of Developmental BioEngineering within the Faculty of Science and Technology at the University of Twente, where she also holds an appointment at the TechMed Centre. She heads the Quantitative Biology Labs (Post Lab), employing a quantitative biology approach that integrates molecular biology, biophysics, and computational modeling to unravel the mechanisms by which cellular communication dictates cell fate. Her research focuses on cartilage biology, particularly the regulation of cartilage hypertrophy and degenerative diseases such as osteoarthritis. Post employs a variety of techniques, including mechanistic and AI-based models like deep learning, to develop digital twins of biological systems for studying tissue formation, health, and disease, with applications in diagnostics and precision therapies. She has co-developed the modeling tool ANIMO and computational models such as ECHO for signal transduction networks in chondrocytes.
Post earned her PhD in Molecular Oncology from Memorial University of Newfoundland in 2002, following which she conducted postdoctoral research at the Max Planck Institute for Biophysical Chemistry from 2002 to 2005. She joined the University of Twente in 2001. Her scholarly output includes over 127 research items, with notable publications such as 'Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology' (Advanced Science, 2024), 'Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis' (Journal of Cellular Physiology, 2024), 'TF-FRAP reveals number of cells in a subpopulation in hMSCs determines its differentiation potential' (Osteoarthritis and Cartilage, 2024), 'Molecular insights into heart field-specific cardiomyocyte differentiation - A computational study: Boolean model of cardiac development' (PLoS ONE, 2026), and 'DANSE: A pipeline for dynamic modelling of time-series multi-omics data' (BMC Bioinformatics, 2026). She received the Stimuleringsfonds award from the University of Twente in 2010 and serves as Chair of the Nederlandse Vereniging voor Biochemie en Moleculaire Biologie (NVBMB) since 2025. Her work contributes to UN Sustainable Development Goals 3 (Good Health and Well-being) and 10 (Reduced Inequalities).
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