Rate My Professor Jacqueline Matthews

Matthews employs structural biology, biophysical, and molecular biology approaches to study protein-protein and protein-nucleic acid interactions in gene regulation. Her research elucidates the molecular mechanisms by which proteins bind DNA to switch genes on or off, processes vital for normal development and implicated in diseases such as cancer. Notable publications include "mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome" (2023), "The molecular details of a novel phosphorylation-dependent interaction between MRN and the SOSS complex" (2023), "DNA-binding, multivalent interactions and phase separation in transcriptional activation" (2023), and "Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elasticity" (PNAS, 2012). She has secured Australian Research Council funding, including grants DP220101489 and LE110100171. With over 7,400 citations, her contributions have advanced protein chemistry. Matthews serves as President of the Lorne Conference on Protein Structure and Function, has led the Australian Society for Biochemistry and Molecular Biology, edited "Protein Dimerization and Oligomerization in Biology" (2016), teaches Biochemistry and Molecular Biology, supervises PhD students, and promotes women in science via conference committees.