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About Guy
Associate Professor Guy Jameson is a bioinorganic chemist in the School of Chemistry within the Faculty of Science at the University of Melbourne, where he has served since 2017. Born and raised in Dundee, Scotland, he completed his undergraduate studies at University College, Oxford, focusing on proton-coupled electron transfer to iron-sulfur cluster proteins under Professor Fraser Armstrong. His doctoral research on catecholamine chemistry was conducted at the Technical University of Vienna under Professor Wolfgang Linert. Following a postdoctoral fellowship with Professor Vincent Huynh in the Physics Department at Emory University, where he studied iron-containing metalloproteins using Mössbauer and EPR spectroscopy, Jameson began his independent academic career at the University of Otago in New Zealand in 2006. There, he progressed from Lecturer to Senior Lecturer and Associate Professor until 2016. During his time at Otago, he received the Hill-Tinsley Research Medal from the New Zealand Association of Scientists and was elected a Fellow of the New Zealand Institute of Chemistry. He holds memberships in the American Chemical Society, Society of Bioinorganic Chemistry, and American Association of Biochemistry and Molecular Biology.
Jameson's research centers on the spectroscopic and mechanistic investigations of metalloproteins, particularly iron-oxygen reactivity in biological systems. His lab explores thiol dioxygenases that oxidize thiols to sulfinates, heme-containing peroxidases such as lactoperoxidase involved in innate immunity, and ferritin's role in cellular iron storage and release. Employing molecular biology for protein expression and purification, alongside fast-flow kinetics and spectroscopic techniques including Mössbauer, EPR, and NMR spectroscopy, his work elucidates enzyme mechanisms and iron regulation in physiological and pathophysiological contexts. Key publications include 'Observation of Radical Rebound in a Mononuclear Nonheme Iron Hydroxylase' (Journal of the American Chemical Society, 2018), 'Substrate Specificity in Thiol Dioxygenases' (Biochemistry, 2019), 'Biochemical Characterization of Caenorhabditis elegans Ferritins' (Biochemistry, 2023), and contributions to studies on nitrogenase scaffold protein NifU and 3D-printed MOF-heteropoly acid nanozymes. Jameson serves on the editorial board of the Journal of Inorganic Biochemistry and has delivered lectures, including the first Melbourne University Chemical Society Lecture in 2022. His interdisciplinary approaches advance understanding of iron metabolism and metalloprotein function.
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