Rate My Professor Flora Lee

Dr. Flora Lee is a Wellcome Early-Career Research Fellow in Developmental Neurobiology at King’s College London. She is affiliated with the Centre for Developmental Neurobiology in the Institute of Psychiatry, Psychology and Neuroscience and the MRC Centre for Neurodevelopmental Disorders. Her research examines RNA regulatory mechanisms, with emphasis on RNA-binding proteins, their interactions with RNA structures, alternative splicing, phase separation, and control of translation in the context of neurodevelopment and neurodegenerative diseases such as tauopathies. Lee develops and applies advanced techniques like hiCLIP and RIC-seq to map protein-RNA interactions. She collaborates with prominent researchers including Jernej Ule at the Francis Crick Institute, Nicholas M. Luscombe, and teams at King’s College London.

Lee has authored or co-authored impactful publications in leading journals. These include 'TDP-43 condensation properties specify its RNA-binding preferences and phase separation in vitro and in vivo' (Cell, 2021); 'A computationally-enhanced hiCLIP atlas reveals Staufen1-RNA binding features and links 3' UTR structure to RNA metabolism' (Nucleic Acids Research, 2023); 'HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion' (The EMBO Journal, 2023); 'Subcytoplasmic location of translation controls protein output' (Molecular Cell, 2023); and 'Poised PABP–RNA hubs implement signal-dependent translation' (Nature Structural & Molecular Biology, 2024). Her publications have received over 70 citations as per King’s College London Pure portal and higher counts elsewhere, demonstrating growing influence. She is currently involved in projects with Dr. Miha Modic, Dr. Laura Andreae, and Prof. Eugene Makeyev to study MAPT regulation in cellular homeostasis and its dysregulation in tauopathies. Supported by the Wellcome Trust Early-Career Fellowship, her work contributes to understanding RNA networks in brain development and disease.