Rate My Professor Fabrice Jaffré,

Jaffré's research centers on elucidating the molecular mechanisms driving abnormal cardiac development in congenital heart defects and cardiomyopathies, particularly in children with rare genetic disorders such as Noonan syndrome and Hardikar syndrome. His laboratory utilizes hiPSCs through cardiac directed differentiation, CRISPR genome editing, multi-omics analyses, 3D organoids, and engineered heart tissues to model development and disease, aiming to identify novel therapeutic strategies. Current efforts are backed by the Additional Ventures Single Ventricle Research Fund Award. Notable publications include "HiPSCs as a Unique Platform to Model Cardiogenesis in NOTCH1-Associated HLHS: hiPSCs to Model Complex Congenital Heart Defects" (Circulation Research, 2023), "Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children" (Science, 2023), "Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes" (Stem Cell Research & Therapy, 2023), "An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts" (Circulation Research, 2021), and "Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2" (Stem Cell Reports, 2021).