Rate My Professor Evan Ingley

Associate Professor Evan Ingley is a Lecturer in Clinical Biochemistry at Murdoch University, where he contributes to teaching and research in the fields of biochemistry and molecular biology. Affiliated with the School of Veterinary and Life Sciences and the School of Medical, Molecular and Forensic Sciences, Ingley also heads the Cell Signalling Group at the Harry Perkins Institute of Medical Research and maintains an association with the University of Western Australia. He earned his PhD in Biochemistry and Molecular Biology from the Australian National University in 1992. Throughout his career, Ingley has focused on elucidating the complex signalling networks that regulate cellular processes, with a particular emphasis on protein tyrosine kinases and their roles in health and disease states such as cancer, blood disorders, and cardiovascular conditions.

Ingley's research has produced significant publications in leading journals. Key works include 'Functions of the Lyn tyrosine kinase in health and disease' (Biochemical Journal, 2012), which explores the multifaceted roles of Lyn in cellular signalling; 'The SH2 interactome: Development and utility of a phospho-tyrosine-specific yeast two-hybrid system to identify and analyse signalling pathways' (2020); 'Crystal structures of the Lyn protein tyrosine kinase domain reveal a novel activating conformation and unique autophosphorylation sites' (Journal of Biological Chemistry, 2009); 'MADM, a novel adaptor protein that mediates receptor to Ras/MAPK activation' (Journal of Biological Chemistry, 2002); 'SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 recruitment' (Cell Reports, 2021); 'Lyn kinase plays important roles in erythroid expansion, maturation, and survival' (Biochemical Journal, 2016); and 'Identification of novel sarcoma risk genes using a two-stage genome-wide association study' (Journal of Medical Genetics, 2019). These contributions have advanced knowledge of Lyn kinase activity in erythroleukemia cell survival, sarcoma genetics, and phospho-tyrosine interactomes. His studies on topics like injury-initiated atherogenesis and novel protein kinase substrates further demonstrate his impact on understanding signalling pathways in disease contexts. Ingley's work underscores the importance of precise kinase regulation in cellular homeostasis and pathology.