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Rate My Professor Ellen Rothenberg

CalTech - California Institute of Technology

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5.04/23/2026

Always approachable and easy to talk to.

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About Ellen

Ellen Rothenberg is the Edward B. Lewis Professor of Biology in the Division of Biology and Biological Engineering at the California Institute of Technology. Her laboratory studies the molecular mechanisms responsible for developmental lineage choice as hematopoietic stem cells differentiate into T lymphocytes. This research examines how transcription factors and signaling events induce T-lineage gene expression in uncommitted precursors, force relinquishment of other developmental options, and interact with changing chromatin landscapes to ensure the kinetics and irreversibility of lineage commitment. Approaches include in vitro developmental biology, high-resolution single-cell characterization, retroviral perturbation, and genome-wide analyses. Additional interests encompass variations in this pathway predisposing to autoimmunity and evolutionary origins of T, B, and innate lymphocyte programs through comparative analysis of basal vertebrates.

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