Rate My Professor Don Nguyen

Recent studies from the Nguyen laboratory have elucidated the role of cell lineage control during tumor progression, epigenetic regulation of cell-cell communication in disseminating tumor cells, and mechanistic links between drug resistance and brain metastasis. Key publications include "Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis" (Cancer Cell, 2013), "Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6" (Oncogene, 2020), "Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer" (Nature Communications, 2022), "An in vivo screen identifies NAT10 as a master regulator of brain metastasis" (Science Advances, 2025), and "Preclinical Models of Solid Cancers for Testing Cancer Immunotherapies" (Annual Review of Cancer Biology, 2025). Nguyen co-leads the Cancer Signaling Networks program at Yale Cancer Center and serves as Co-Director of the Pathology and Molecular Medicine Graduate Program. His honors include the IASLC Young Investigator Award (2012), Stewart Trust Scholar (2013), 2013 Basic Research Prize (Yale Cancer Center), Yale Center for Clinical Investigation Scholar (2011), and Class of 1961 Cancer Research Award (2021).