Rate My Professor Dhananjie Chandrasekera

Chandrasekera's research specializes in the molecular mechanisms of diabetic heart disease, encompassing exosomal microRNAs, epigenetic regulation, and vascular repair processes in the context of diabetes-induced cardiac pathology. He is the lead author of the review 'Exosomal microRNAs in diabetic heart disease,' published in Cardiovascular Diabetology in 2022, which elucidates the biogenesis and function of exosomes, their alterations in cardiovascular disease, and their specific roles in diabetic cardiomyopathy through dysregulated miRNA cargo, highlighting potential biomarkers and therapeutic targets. Other key publications include 'METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miR-18a-5p Expression in Endothelial Cells' in Arteriosclerosis, Thrombosis, and Vascular Biology (2021), demonstrating how METTL3-mediated m6A RNA methylation promotes angiogenesis via specific miRNAs; 'Dysregulation of ghrelin in diabetes impairs the vascular reparative actions of endothelial progenitor cells' in Scientific Reports (2020); and 'Diabetes induces dysregulation of microRNAs associated with stem cell survival, proliferation and differentiation' in Diabetologia (2021). In 2024-2025, he edited multiple chapters in 'Cardiomyocytes: Methods and Protocols,' providing protocols for cardiomyocyte protein extraction, endothelial cell isolation from human internal mammary artery, cationic liposome formulation for miRNA delivery, human atrial trabeculae preparation, and sympathetic nerve traffic quantification to the heart. His publications have garnered over 215 citations on Google Scholar, underscoring his contributions to advancing knowledge in diabetic cardiomyopathy and related fields.