Debnath Ghosal

Debnath Ghosal is an Associate Professor in the Department of Biochemistry and Pharmacology, Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne, where he heads the Ghosal Laboratory at the Bio21 Molecular Science and Biotechnology Institute. An NHMRC Emerging Leadership Fellow, he received his PhD in structural biology from the MRC Laboratory of Molecular Biology, University of Cambridge, and his Master's degree from the Tata Institute of Fundamental Research. He joined the University of Melbourne in March 2020 following postdoctoral research, including at Caltech.

Ghosal's research focuses on in situ structural biology, utilizing electron cryotomography to reveal the native structures of macromolecular complexes within intact bacterial cells. His laboratory examines bacterial secretion systems involved in toxin delivery and cytomotive filaments that underpin cellular processes such as motility, cell division, and communication. Techniques employed include correlative light and electron microscopy, focused ion beam milling, biochemical reconstitution, fluorescence imaging, X-ray crystallography, and cryo-EM. He has secured major funding, including the Cumming Global Centre Foundation Grant for a structural cell biology platform targeting pandemic pathogens, HFSP Research Grant, NHMRC Investigator Grant on host cytoskeleton during pathogen invasion, and ARC Discovery Project grant. Key publications include 'Archaic chaperone-usher pili self-secrete into superelastic zigzag springs' (Nature, 2022), 'Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes' (Nature Communications, 2025), 'A bacterial host factor confines phage localization for excluding the infected compartment through cell division' (Cell Reports, 2025), and 'In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS' (FEBS Letters, 2026). With over 1,300 citations on Google Scholar, his work significantly impacts bacterial cell biology and infection research.

Professional Email: debnath.ghosal@unimelb.edu.au