Rate My Professor Daniel Tennant

Tennant's research employs stable isotope tracers to study alterations in nutrient utilization under hypoxic conditions or due to genetic mutations mimicking hypoxia, with applications to disease pathogenesis, especially cancer. He directs the Metabolic Tracer Analysis Core (MTAC) within the department, advancing techniques for metabolic analysis in cells and tissues. His laboratory investigates cellular metabolic modulation in hypoxia and metabolic reprogramming by tumor genetics. Tennant has authored numerous publications in prestigious journals. Notable works include: Eales et al. (2016) "Hypoxia and metabolic adaptation of cancer cells" in Oncogenesis; Lussey-Lepoutre et al. (2015) "Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism" in Nature Communications; Hollinshead et al. (2018) "Oncogenic IDH1 mutations promote enhanced proline synthesis through pycr1 to support the maintenance of mitochondrial redox homeostasis" in Cell Reports; and recent papers such as Fulton-Ward et al. (2025) "mTOR activity and metabolic reprogramming of CD8+ T cells is impaired under hypoxia and within the multiple myeloma bone marrow" in Blood Advances. He supervises doctoral students on these topics, contributes as a peer reviewer for BMC Cell Biology, and delivers invited talks at international conferences including the American Association for Cancer Research and European Association of Neuro-oncology.