Rate My Professor Daniel Kim-Shapiro

His biophysics research centers on nitric oxide and nitrite reactions with hemoglobin in cardiovascular physiology, including nitrite reduction to nitric oxide by deoxyhemoglobin for vasodilation, hemoglobin's nitrite reductase activity under allosteric control, and nitrite's roles in hypoxic signaling, cytoprotection, and as a vascular endocrine nitric oxide reservoir. The Kim-Shapiro lab applies physical and biological tools to cardiovascular health challenges such as blood storage lesions, sickle cell disease, and dietary nitrate effects on exercise endurance in aging and heart failure. Key publications include "Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation" (Nature Medicine, 2003), "Nitrate and nitrite in biology, nutrition and therapeutics" (Nature Chemical Biology, 2009), "The emerging biology of the nitrite anion" (Nature Chemical Biology, 2005), and "Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control" (Journal of Clinical Investigation, 2005). The lab has received continuous funding from the NIH Heart, Lung, and Blood Institute for over ten years and from the American Heart Association. Kim-Shapiro is co-inventor on patents such as "Use of Nitrite Salts for the Treatment of Cardiovascular Conditions." Awards include the Excellence in Research Award in 2002 and appointment as the first Harbert Family Distinguished Chair in 2009.