Rate My Professor Christopher Grainge

Christopher Grainge is a Conjoint Associate Professor in the School of Medicine and Public Health at the University of Newcastle. He completed his undergraduate medical training at Imperial College, University of London, including an intercalated BSc with a period of research at Washington University, St Louis, USA. Grainge served as a medical officer in the Royal Navy, with deployments to the Caribbean on HMS Norfolk, Antarctica on HMS Endurance supporting a scientific programme, and Southern Iraq as one of two physicians at the British military hospital in Shaibah. His senior house officer training occurred at Derriford Hospital in Plymouth, where he obtained membership of the Royal College of Physicians. Specialist training in Respiratory, Sleep, and General Medicine took place in Wales, Portsmouth, and the University of Southampton, where he worked with Professor Stephen Holgate’s group and was awarded his PhD in 2011. This research examined the effect of repeated bronchoconstriction on the airways in asthma, leading to international presentations, peer-reviewed articles, and a first-author paper in the New England Journal of Medicine titled "Effect of Bronchoconstriction on Airway Remodeling in Asthma" (2011). He collaborated with the Defence Science and Technology Laboratories at Porton Down on acute lung injury, earning the Gilbert Blane Medal from the Presidents of the Royal College of Physicians and Royal College of Surgeons (2010).

Prior to his current roles as Staff Specialist in Respiratory and General Medicine at John Hunter Hospital and Conjoint Associate Professor at the University of Newcastle, Grainge was appointed Consultant Physician in Respiratory, Sleep, and General Medicine at University Hospital Southampton and Senior Lecturer in Medicine at the University of Southampton. His research interests encompass the role of mechanical forces in asthma pathophysiology, environmental dusts in lung disease pathogenesis including constrictive bronchiolitis from inhaled particles, and platelet antagonists on allergen challenge in asthma. Clinical interests include difficult asthma and interstitial lung disease. He has received grants from the British Lung Foundation, Southampton Marine and Maritime Institute, Institute for Life Sciences, and Gerald Kerkut Foundation. Additional awards include the University of Southampton Translational Medicine Research Prize (2011), Military and Civilian Health Partnership Awards Winner (2011), Michael Arthur Clinical Research Prize (2014), and Leatherdale Prize for Clinical Teaching Finalist (2013). Key publications include "Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study" (The Lancet Respiratory Medicine, 2020), "Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis" (American Journal of Physiology-Lung Cellular and Molecular Physiology, 2018), and "Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma" (PLoS One, 2014). Grainge serves on the editorial board of Respirology Case Reports since 2013.