Rate My Professor Christophe Lefevre

Christophe Lefevre serves as Conjoint Associate Professor in the School of Medicine and Public Health within the College of Health, Medicine and Wellbeing at the University of Newcastle, Australia. He holds the position of Senior Bioinformatician at the Hunter Medical Research Institute (HMRI) in Newcastle, where he applies advanced computational methods to genomic data analysis. Previously, Lefevre was Associate Professor of Bioinformatics at Deakin University's Centre for Biotechnology and Interdisciplinary Sciences (BioDeakin) in Geelong from February 2008 to March 2015. His expertise encompasses bioinformatics and computational biology, with specialized skills in epigenetics, microarray analysis, gene expression profiling, genomics, DNA sequencing, and the biology of milk and lactation across diverse mammalian species including monotremes, marsupials, and therians.

Lefevre's research has significantly advanced the understanding of mammary gland development, lactation evolution, and the functional roles of milk components. Key publications include 'Insulin regulates human mammosphere development and function' (2021), which assesses lactogenic hormones in mammary gland models; 'Milk: Milk of Monotremes and Marsupials' (2021), exploring non-nutritional functions of milk; 'Defining the origin and function of bovine milk proteins through genomics: The biological implications of manipulation and modification' (2020); 'The comparative genomics of monotremes, marsupials, and pinnipeds: Models to examine functions of milk proteins' (2020); and 'Comparative analysis of milk microRNA in the therian lineage highlights the evolution of lactation' (2019), quantifying miRNAs in mammalian milk. Additional works cover gene expression in marsupial lung development ('Gene expression profiling of postnatal lung development in the marsupial gray short-tailed opossum', 2018), dietary cows’ milk protein and type 1 diabetes ('Dietary Cows’ Milk Protein A1 Beta-Casein Increases the Incidence of T1D in NOD Mice', 2018), mammary extracellular matrix effects on cancer cells (2018), and transcriptome analysis revealing extracellular matrix roles (2017). In recent years, Lefevre has contributed bioinformatics expertise to large-scale genome-wide association studies, including 'A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals' (2024), 'Genome-wide gene-sleep interaction study identifies novel lipid loci' (2025), and analyses for glioblastoma cell lines and lung clearance indices. His 186 publications have garnered over 4,000 citations, underscoring his impact in bioinformatics, lactation biology, and medical genomics.