Carrie Lucas

Carrie L. Lucas is an Associate Professor of Immunobiology at Yale University School of Medicine. She earned her PhD from Harvard University in 2011 and her BS from the University of North Carolina at Chapel Hill in 2006, followed by postdoctoral training at the National Institutes of Health, NIAID, which she completed in 2016. Since establishing her laboratory in 2016 within the Department of Immunobiology, Dr. Lucas has focused on discovering single-gene defects underlying severe immune disorders in humans. Her research employs human genomics, in vitro studies with primary patient cells, and in vivo genetically engineered mouse models to elucidate genetic, cellular, and biochemical mechanisms driving rare immune disorders. These efforts illuminate fundamental principles of immunology relevant to diagnoses and treatments. Her research interests encompass hereditary autoinflammatory diseases, immunologic deficiency syndromes, immunoproliferative disorders, inflammation, signal transduction, T-lymphocytes, and phosphoinositide 3-kinase (PI3K) signaling pathways, particularly in immunodeficient patients with PI3K mutations.

Dr. Lucas has garnered significant recognition for her contributions, including the Enders Faculty Fellow award from Yale School of Medicine (2023), Christina Fleischmann Award to Young Women Investigators from the International Cytokine & Interferon Society (2020), CRI CLIP Award from the Cancer Research Institute (2019), Bohmfalk Scholar from Yale School of Medicine (2018), and Charles Hood Foundation Child Health Research Award (2017). Key publications include "Dominant-activating germline mutations in the gene encoding the PI (3) K catalytic subunit p110δ result in T cell senescence and human immunodeficiency" (Nature Immunology, 2014), "Clinical and immunologic phenotype associated with activated phosphoinositide 3-kinase δ syndrome 2: a cohort study" (Journal of Allergy and Clinical Immunology, 2016), "PI3Kδ and primary immunodeficiencies" (Nature Reviews Immunology, 2016), "Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology" (2019), "Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children" (Immunity, 2021), and "PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells" (2024). She serves as Director of Graduate Studies for the Immunobiology program at Yale Graduate School of Arts and Sciences and holds affiliations with the Human and Translational Immunology Program, Yale Center for Genomic Health, Yale Center for Immuno-Oncology, and Yale Center for Systems and Engineering Immunology. Her work has advanced the understanding of primary immunodeficiencies and autoinflammatory diseases.

Professional Email: carrie.lucas@yale.edu