Rate My Professor Andreas Linninger

Andreas Linninger is a Professor in the Richard and Loan Hill Department of Biomedical Engineering in the College of Engineering at the University of Illinois at Chicago, where he has served since 1997. He earned his PhD from Vienna University and directs the Laboratory for Product and Process Design. Linninger's research centers on cerebral hemodynamics and metabolism, elucidating mechanisms of cerebral blood flow regulation in normal conditions and diseases such as stroke. His team integrates computational modeling with experimental approaches, including cell cultures, animal models, and non-invasive human imaging techniques like MRI and digital subtraction angiography, to quantify transport phenomena and pharmacokinetic processes in the brain. He pioneered quantitative methods for metabolism and hemodynamics, contributing to advanced digital models of brain function.

Linninger's expertise extends to innovative drug delivery strategies for the central nervous system, encompassing convection-enhanced delivery, electromagnetic guidance of nanoparticles, and intrathecal administration, supported by computational predictions of dose-response relationships. He investigates hydrocephalus pathophysiology, focusing on brain aquaporins in water clearance and developing pharmacological treatments targeting molecular water transport. Notable publications include 'Cerebrospinal fluid dynamics coupled to the global circulation in the human brain' (2021), 'Vascular synthesis based on hemodynamic efficiency principle' (2023), 'Cerebrospinal fluid volume measurements in hydrocephalic rats' (2012), and 'Model and Parameter Uncertainty in Distributed Systems' (2006). In recognition of his contributions, Linninger was elected to the American Institute for Medical and Biological Engineering College of Fellows in 2020 and received the Hydrocephalus Association Innovator Award in 2015. His work advances understanding of brain diseases like Alzheimer's and hydrocephalus, influencing bioengineering, neurosurgery, and therapeutic development through species-specific computational platforms and NIH-funded projects. He has also led educational initiatives, including the RET program in Engineering and Computer Science.