Rate My Professor Albert Lee

Associate Professor Albert Lee, PhD, FHEA, is an Associate Professor at Macquarie Medical School and leader of the Neuroproteomics Research Team at the Motor Neuron Disease Research Centre, Macquarie University. He earned his PhD at Macquarie University and holds Fellowship of the Higher Education Academy. His career is focused on medical research and education in the tertiary sector. Previously, he served as a Senior Lecturer in the Department of Biomedical Sciences within the Faculty of Medicine and Health Sciences, where he developed diagnostic assessment strategies and contributed to teaching in biomedical sciences. Lee's work emphasizes building relationships with clinical and research partners to advance understanding of neurodegenerative diseases.

Lee's research investigates dynamic proteomic changes during cellular stress and survival in motor neurons, particularly in motor neuron disease (MND) and amyotrophic lateral sclerosis (ALS). His team utilizes advanced neuroproteomics to profile molecular mechanisms, including TDP-43 aggregation, protein folding responses, and RNA-binding properties. Key publications include 'A transient protein folding response targets aggregation in the endoplasmic reticulum during ALS/FTD' (Nature Communications, 2024), 'Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 (M337V) aggregation in zebrafish' (2021), 'Critical impact of lysine 136 in TDP-43 phase separation, compartmentalization, and aggregation' (iScience, 2025), 'Identification of phosphorylated tau protein interactors in progressive supranuclear palsy' (2023), and proteomic datasets such as 'Inter-regional proteomic profiling of the human brain' (2023) and 'Cardio-metabolic and cytoskeletal proteomic signatures' (2025). He has authored over 100 publications with more than 2,700 citations. Awards include the Early Career Award from the Australasian Proteomics Society, a prize-winning poster at the 2016 MND symposium in Dublin, and the Charcot Award from MND Australia. In 2025, Lee was primary chief investigator for a $3.5 million grant to accelerate MND research through neuroproteomics. He serves on the editorial board of Communications Biology and contributes to committee roles in proteomics and neurodegeneration research.