23 postdoctoral scientist jobs found in Oxford

Centre for Medicines Discovery, NDM Research Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ We have an exciting opportunity for a Postdoctoral Scientist with expertise in enzymology and biochemistry to join the ARUK-ODDI. Based at the Nuffield Department of Medicine, you will join The Alzheimer’s Research UK Oxford Drug Discovery Institute (ARUK-ODDI), which is one of three research institutes sponsored by Alzheimer’s Research UK and charged with uncovering novel therapeutic approaches for dementia. Reporting to the Assay Development and Screening Team Leader, you will employ cutting-edge biochemical and biophysical research techniques to carry out biophysical characterisation of new proteins and develop biochemical and biophysical assays that will allow for the discovery of new chemical matter. You will be a key member of target-based project teams that ‘own’ a project and, by designing and implementing screening and compound evaluation...

Target Discovery Institute, NDM Research Building, Old Road Campus, Heading, Oxford, OX3 7BN We are seeking to appoint a Postdoctoral scientist with experience in protein purification, biophysical characterization of protein ligand interactions, functional assay development as well as crystallization and structure determination of proteins. You will join the CMD Chemical Biology Group at the Target Discovery Institute, Nuffield Department of Medicine. You will be responsible for unravelling the fundamental role of novel RNA binding proteins involved in human disease. You will be developing biochemical assays and studying the interaction of low molecular weight modulators to protein interaction domains and understand the SAR (structure activity relationship) of compound classes with the goal to develop a highly selective first- in-class chemical probes. You will contribute to the scientific output by publishing high quality manuscripts and by representing the group on...

Ludwig Institute for Cancer Research, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ We are seeking to appoint a Postdoctoral Research Scientist to join the Ludwig Institute for Cancer Research. You will collaborate with members of the Professor Shi’s lab in understanding cancer and immune cell biology. You will adapt existing and developing new scientific techniques and experimental protocols and also design and perform original research in the existing projects investigating cancer cell plasticity and immune cell functions. You will test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will be responsible to manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. It is essential that you hold a PhD (or close to completion) in immunology or a relevant...

Department of Physiology, Anatomy & Genetics, Sherrington Building, Parks Road, Oxford, OX1 3PT Postdoctoral Research Scientist Full time, Fixed term post until 23rd May 2026 Grade 7: £34,308 - £42,155 per annum This is an exciting opportunity for a Postdoctoral Research Scientist to join the Lakhal-Littleton lab and contribute to our research. Reporting to Prof Lakhal-Littleton, the successful as a member of a research group will be responsible for carrying out research to understand the role of cardiac hepcidin/ferroportin axis in the management of iron deficiency in heart failure. The post holder will provide guidance to less experienced members of the research group, including postdocs, research assistants, technicians, as well as PhD and project students. The researcher will be managing the role of hepcidin in heart failure project, carrying out experiments independently and contributing to data analysis and interpretation. They will also...

Ludwig Institute for Cancer Research, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ We are seeking to appoint a Senior Postdoctoral Research Scientist to join the Ludwig Institute for Cancer Research. You will participate in the Ludwig Cancer Research funded research programme led by Prof Skirmantas Kriaucionis, Dr Benjamin Schuster-Böckler, Prof Chunxiao Song, Prof Xin Lu, and provide statistical analysis plans for studies while contributing to the overall planning of studies. You will be responsible for advising laboratory and other bio-statistical staff working on relevant projects, and assisting others in their work where appropriate. You will conduct detailed analysis of datasets, as well as develop and tailor methodologies for analysis and data collection in collaboration with members of the research team. It is essential that you hold a PhD in Biostatistics, Mathematics, Statistics, Computing, Mathematical Biology or a related subject....

Division of Structural Biology, Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Old Road Campus, Headington, Oxford, OX3 7BN We are seeking an ambitious and highly motivated Postdoctoral Research Scientist to join the research Group of Professor Jonathan Grimes, located in the Division for Structural Biology, at the Nuffield Department of Medicine. You join a Wellcome Trust-Funded Project to understand in molecular detail Influenza virus replication and transcription, and the process of viral assembly. You will be responsible for managing your own academic research activities, which involves small scale project management to co-ordinate multiple aspects of work and meet deadlines. You will adapt existing and develop new scientific techniques and experimental protocols, and test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will contribute ideas for new research projects, and...

Wellcome Centre Human Genetics, Roosevelt Drive, Old Road Campus, Headington, Oxford, OX3 7BN We are seeking to appoint a highly motivated Postdoctoral Research Scientist in Cancer Genetics to join the research group led by Professor Simon Leedham at the Wellcome Centre for Genetics. You will be responsible for developing and deploying existing and new experimental tumour models of colorectal cancer to assess the dynamic and adaptive stem cell molecular phenotype, assessing how this relates to model genotype and the influence of therapeutic selective pressures. You will design, plan and execute experiments and undertake detailed molecular and morphological phenotyping of resultant models, using available technologies such as single cell ‘omic analysis and multiple IHC assessment. It is essential that you hold a PhD (or close to completion) in molecular biology or relevant subject and a personal home office licence (or equivalent qualification for your country of...

Ludwig Institute for Cancer Research, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ & Target Discovery Institute, NDM Research Building, Old Road Campus, Heading, Oxford, OX3 7BN We are seeking to appoint a Postdoctoral Researcher - Chemistry & Cancer to join the Ludwig Institute for Cancer Research. You will be part of larger team carrying out research into identifying small molecule inhibitors for newly identified RNA m6A enzymes. You will be co-supervised by Dr Paul Brannen at CMD of Oxford and Professor Yang Shi at Ludwig Cancer Research and work in a multi-disciplinary team consisting of other chemists, biochemists and cell biologists and provide medicinal chemistry support for the project. Your primary responsibility will be to design and synthesise new small molecules for RNA m6A enzymes with potential applications in cancer.   It is essential that you hold a PhD (or close to completion) in organic synthesis or medicinal...

Department of Physiology, Anatomy and Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU Full-time, fixed term for 3 years This opportunity has arisen to join Professors Vladyslav Vyazovskiy and Zoltan Mólnar on their BBSRC project grant entitled “Brain mechanisms of sleep: top-down or bottom-up?”. The aim of the project is to identify the role of specific cortical and cortico-subcortical projections in sleep regulation. We will apply a combination of cutting-edge methodologies in the mouse model. This will include in vivo electrophysiology, neuroanatomical tracing methods, chemogenetics and circadian manipulations. The post holder’s duties will include: managing your own academic research and administrative activities; adapting existing and developing new scientific techniques; testing hypotheses and analysing scientific data; contributing ideas for new research projects;...

11a Mansfield Road, Oxford, OX1 3SZ The overexploitation of wildlife is a key threat to biodiversity, exemplified by pangolins. The University of Oxford is seeking a Post-Doctoral Research Assistant to play a key role in the multi-year international research project, “Operation Pangolin: Unifying Diverse Data Streams to Redefine Species Conservation.” The postholder will be an experienced social scientist, with expertise in conducting fieldwork and data analysis to understand social-ecological systems, including institutional arrangements. They will design and execute research to understand the systems in which pangolins are used and traded in Central Africa and work with relevant stakeholders to devise conservation solutions. They will use a combination of research approaches and methods (e.g., institutional diagnostics).  The successful candidate will have: a relevant Ph.D./D.Phil. (or be near to completion, i.e., about to submit); experience of designing...

Nuffield Department of Women’s & Reproductive Health (NDWRH), The Women’s Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU An exciting opportunity for a postdoctoral researcher is available in the Oxford Labour Monitoring (OLM) group at the Nuffield Department of Women’s and Reproductive Health. We are looking for a motivated and technically adept scientist to join the group as an image analysis researcher. This is an excellent opportunity for candidates who are interest in acquiring experience of research in a world-class academic unit (see http://www.wrh.ox.ac.uk), while contributing to a multi-disciplinary multi-national project of global importance. The post holder will work on a fast-paced innovative project funded by Wellcome Leap (https://wellcomeleap.org/inutero/), which aims to reduce stillbirth rates globally. Our study is developing novel wearable sensors for fetal monitoring in pregnancy. We will develop state-of-the-art image...

The Kennedy Institute of Rheumatology, Roosevelt Drive, Headington, Oxford OX3 7FY, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences. We are seeking a Postdoctoral Research Scientist to join Professor Powrie’s Mucosal Immunology Group at the Kennedy Institute, to work within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford. Professor Powrie is the Director of the Kennedy Institute of Rheumatology. You will join a dynamic and successful group studying immune regulation in the intestine and how this breaks down in inflammatory bowel disease and colorectal cancer. The aim of the project is to investigate how specific genetic mutations can lead to changes in the interactions between immune cell subsets and bacterial species within the intestine, and how specificities in both immune cells and microbes may change in different subsets in health and disease. The project will utilise in...

Applications are invited for a 3-year postdoctoral research position within the Drug Transport and Tumour Metabolism Lab, led by Dr Louise Fets. We are seeking a talented scientist to deliver an exciting and innovative research project funded by a 6-year Cancer Research UK-funded Career Establishment Award on “Understanding how membrane transporters influence variability in cancer drug uptake and investigating implications for efficacy”.... Job listing information Reference MED03624 Date posted 24 January 2023 Closing date 21 February 2023 Job summary Applications are invited for a 3-year postdoctoral research position within the Drug Transport and Tumour Metabolism Lab, led by Dr Louise Fets. We are seeking a talented scientist to deliver an exciting and innovative research project funded by a 6-year Cancer Research UK-funded Career Establishment Award on “Understanding how membrane transporters influence...

Applications are invited for postdoctoral research position within the Computational Cardiac Imaging Group, led by Prof Declan O’Regan We are seeking a talented scientist with a background in mathematics or computer science with previous experience in cardiac image segmentation and motion analysis.   This post is part of a 4-year NIH program in a partnership between Imperial College London and Brigham and Women’s Hospital using machine... Job listing information Reference MED03554 Date posted 17 January 2023 Closing date 14 February 2023 Job summary Applications are invited for postdoctoral research position within the Computational Cardiac Imaging Group, led by Prof Declan O’Regan We are seeking a talented scientist with a background in mathematics or computer science with previous experience in cardiac image segmentation and motion analysis.   This post is part of a 4-year NIH program in a...

Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, OX3 9DU Contract type: Fixed term for 12 months Hours: Full-time About the role You will work on a new, translational project, funded by the MRC Confidence in Concept fund and industry partner, Oxford Biomedica, to generate antigen-specific, human regulatory B cells (Breg). You will be responsible for the development and implementation of lentiviral platforms and CRISPR/Cas9 techniques to deliver genes encoding B cell receptor constructs to primary human B cells. Successful realisation of this project will demonstrate proof of concept design of precision B cell therapies in transplantation and immune-mediated disorders. You will be based within the Nuffield Department of Surgical Sciences in the John Radcliffe Hospital, as your normal place of work This position offers a unique opportunity to contribute to the work of an internationally recognised team of scientists and...

Department of Chemistry, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA Applications are invited for a Postdoctoral Research Associate to work on a research project entitled “Small molecule modulation of metabolic function and new target discovery in human cellular models”, working under the supervision of Professor Angela Russell for a period of up to 24 months. This project is funded by Novo Nordisk and is carried out in close collaboration with scientists at Novo Nordisk Research Centre Oxford (NNRCO). This is an exciting opportunity to work in an industry-academia collaboration with world leading researchers and contribute to the development of innovative new therapeutic approaches for metabolic disorders, an area of significant unmet medical need.  Find out more about the Russell group’s research at: russell group   Applicants must hold a PhD in Organic Chemistry, Medicinal Chemistry or Chemical Biology or a related...

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Roosevelt Drive, Headington, Oxford OX3 7FY. We are looking a talented Postdoctoral Research Assistant to join the group of Associate Professor Tal Arnon at the Kennedy Institute, the University of Oxford. The project will explore molecular and dynamic mechanisms that regulate humoral immunity in the lung with emphasis on the roles of resident memory B cells in this process. An important advance from the past decade has been the recognition that adaptive immune cells are not only capable of remembering the antigens they encountered but also the specific sites in which these encounters occurred, such that tissues that are susceptible for infection are reinforced with protective clones. This type of localized immunity proved highly effective in the case of resident memory T cells, leading to accelerated pathogen clearance and reduced widespread of infection in...

RDM Investigative Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford We are seeking an ambitious and creative researcher to investigate the role of key intestinal G-protein coupled receptors (GPCRs) in host environment dialogue, in health and inflammatory bowel disease (IBD).  The work will involve exploring the activity of GPRCs expressed at intestinal barrier surfaces, defining ligands and niche factors modulating barrier GPCR activity. The work will also involve studying how specific intestinal expressed GPCRs influence immune cell reactivity, perpetuation and inflammatory responses within the gut mucosa. The work will include use of genome engineering, large scale screens, multimodal single cell analysis, advanced imaging and tissue model creation. Post-holders will undertake a series of cell biological and molecular assays of effector function and use companion in vivo models to explore physiological attributes of intestinal GPCR...

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Roosevelt Drive, Headington, Oxford OX3 7FY. The Kennedy Institute has an exciting oppourtunity for a highly motivated post-doc to join a strong interdisciplinary team investigating the roles of fibroblasts in rheumatoid arthritis under the leadership of Professor Chris Buckley. The team has an opening for a talented computational reseacher to join the group of Associate Professor Stephen Sansom and lead bioinformatic investigations of the cellular basis of disease initiation, development and resolution. This research will take advantage of rich single-cell and spatial transcriptomics datasets from patient cohorts and animal models. Novel findings will be prioritised, validated and tested in close partnership with wet-lab colleagues. The ultimate goal of the project is to understand the roles of different fibroblast subtypes with a view to informing selective...

Department of Engineering Science, Parks Road, Oxford Applications are invited for the Glasstone Research Fellowship, tenable at the University of Oxford in the field of Engineering Science and aligned with one of the research themes of the Department of Engineering Science. The research activities of the department fall under eight broad headings, though there is much overlap in practice: Information Engineering (Robotics, Computer Vision and Machine Learning); Control Engineering; Thermofluids; Materials and Mechanics; Civil and Offshore; Electrical and Optoelectronic; Chemical and Process Engineering; Biomedical Engineering. This prestigious post is a three-year postdoctoral fellowship and is supported by the Glasstone Bequest, which was set up to encourage scientists at an early stage of their career to follow their research interests at Oxford, one of the world’s leading science universities. Preference will be given to candidates who are at an early stage in...