80 faculty science biology jobs found in Cambridge

The University of Cambridge and MRC Mitochondrial Biology Unit (Director: Professor Judy Hirst) wishes to appoint a research assistant to join Dr Alex Whitworth and the Mitochondrial Neurodegeneration group. The Mitochondrial Neurodegeneration group pursues an integrated programme of investigations which elucidate critical homeostatic mechanisms that regulate the integrity of mitochondria and maintain the normal neuronal functioning. In particular, the group uses Drosophila and cellular models to elucidate the molecular mechanisms of pathogenesis of various neurodegenerative diseases such as Parkinson's Disease and Motor Neuron Disease. We are seeking to recruit a well-organised and experienced person, who will provide broad-ranging assistance to the lab including general lab management and maintenance, as well as providing technical and scientific support for a range of projects. The post-holder will perform routine procedures such as molecular cloning and Drosophila stock...

The MRC Biostatistics Unit is one of Europe's leading biostatistics research institutions. Our focus is to deliver new analytical and computational strategies based on sound statistical principles for the challenging tasks facing biomedicine and public health. This position is to work with Prof Thomas Jaki and Dr Pavel Mozgunov within the Design and Analysis of Randomised Trials (DART) research theme of the MRC Biostatistics Unit (BSU). The post-holder will work on translating research outputs of the theme to end-users and will broadly support the research programmes of the DART theme. Specific duties will include: - Developing R-packages and R Shiny Apps; - Maintaining existing statistical software of the group - To lead writing scientific papers and manuals on implemented software; - Support development of short courses Candidates for Research Associate position will have a PhD in Statistics, or a relevant similar discipline. The starting date for the post is the 1st...

We have an exciting opportunity for a highly motivated Research Assistant to join Dr Mike Chapman's research group in the MRC Toxicology Unit. Previous work in the lab quantified the cell surface proteome of primary myeloma for the first time. Using this and other data we have identified immunotherapeutic targets and are establishing novel CAR-T and other immunotherapies against myeloma. We are interrogating these therapies using in vitro and in vivo models in order to optimise their efficacy and toxicity profiles. Ultimately, we will progress the most promising of these therapies to clinical trials through links and collaborations with Addenbrooke's Hospital and the Cambridge Cancer Centre Immunology Program. On the back of a highly successful beginning to this project we have received additional funding for a Research Assistant to join our team, to help advance this exciting project and develop novel CAR-T therapies for myeloma treatment. The successful candidate will work...

The laboratory of Prof. David Savage is seeking a research assistant to join an interdisciplinary team researching the links between obesity/ adipose tissue dysfunction and metabolic disease. The group has longstanding interests in rare human inherited disorders of adipose tissue, widely known as lipodystrophies. Remarkably, these diseases are strongly associated with almost identical metabolic disorders as those associated with obesity. Our lab studies humans, as well as using a range of model organisms and cell-based approaches to advance understanding of the mechanistic basis for these associations. The position is funded by the Wellcome Trust and will enable the successful applicant to join an international network using innovative approaches to tackle major challenges in human health. In this position, you will: - keep detailed and accurate records - play a leading role in laboratory management duties such as ordering, stock checks and organising lab inventories. - work...

We are seeking applications for this exciting joint post between the Cambridge Cancer Trials Centre (CCTC) and the MRC Biostatistics Unit (MRC-BSU). This position is part of a pan-European consortium (Cancer Core Europe) to improve the design and implementation of clinical trials. We seek a statistician interested in developing novel, more efficient clinical trial designs. Particular focus will be on the design of adaptive clinical trial arms, and clinical trials which incorporate novel biomarker endpoints (eg. liquid biopsy or imaging). The vacancy provides an exciting opportunity to make important contributions to clinical research, working with fellow statisticians and with clinical and translational researchers in Cambridge and across the Cancer Core Europe Centres (see below). The MRC Biostatistics Unit is one of Europe's leading biostatistics research institutions. Its focus is to deliver new analytical and computational strategies based on sound statistical principles for...

The Wallace group (https://chr1swallace.github.io) work on understanding mechanisms underlying immune-mediated disease through integrated analysis of omics data. We seek a statistician interested in human genetics who wants to apply machine learning to estimate cell population frequencies from bulk gene expression data. A common approach to identify dysregulated pathways in diseases is to compare gene expression profiles from healthy vs disease samples. However, the cellular composition of many biological samples is heterogeneous, and, given that many disease processes involve cell infiltration and expansion, such comparisons are confounded by changes in cellular composition. In addition, it is generally recognised that rare populations play a critical role in the pathogenesis of complex diseases, therefore, the ability to measure and interpret phenotypic changes between specific conditions at the cell subset level is critical to obtain a detailed understanding of the role of...

An opportunity has arisen for a talented statistician or probabilistic machine learning methods developer to join Dr Paul Kirk's group at the MRC Biostatistics Unit, Cambridge University, as part of the MIMAH (Minimising Mortality from Alcoholic Hepatitis) Consortium; see also: https://www.mimah.org Alcohol related liver disease (ALD) is responsible for more than 6000 deaths a year in the UK and costs the NHS £3.5 billion. Alcoholic hepatitis is a florid presentation of ALD in which patients present with jaundice and liver failure. Unfortunately, around 30% of people admitted to hospital with this condition will die within 3 months. The treatment of alcoholic hepatitis is complicated by the fact that there is inflammation within the liver whilst the patient is very susceptible to infection. As a result, treatment with drugs, such as steroids, which suppress the immune system may exacerbate the risk of infection. We will apply state of the art Bayesian clustering...

Applications are invited for a post-doctoral research associate in Receptor Evolution to work with Prof Uta Paszkowski at the Crop Science Centre, starting between 1 August and 1 September 2021. The beneficial interaction of plants with endomycorrhizal fungi commences via mutual recognition in the rhizosphere. We identified a receptor complex that is required for perception of beneficial fungi by plants [Gutjahr, Gobbato et al., Science (2015), Choi et al., Nat Commun 2020], and also for plant development. Preliminary data suggest that the symbiosis signalling ability is a derived and not an ancestral trait. This project seeks to reproduce the evolutionary trajectory in order to define the protein features that condition signalling specificity. The projected work will involve a high-resolution metagenomics approach combined with functional validation in rice. Applicants must have a solid background in plant molecular genetics; available knowledge in basic bioinformatics, running...

The University of Cambridge wishes to appoint a Postdoctoral Research Associate to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit. The post holder will work within a programme focused on mitochondrial transport proteins, which are crucial for the functioning of mammalian cells. This project is funded by Apollo Therapeutics and focusses on the development of specific inhibitors of the mitochondrial pyruvate carrier (MPC). MPC has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. The human MPC is a heterodimer of two homologous small membrane proteins, forming two distinct complexes either MPC1/MPC2 or MPC1L/MPC2 [1]. The goal is to develop novel inhibitors of human MPC to treat the aforementioned diseases. Thermostability shift and transport assays have already been developed to screen for better and more specific...

The University of Cambridge wishes to appoint a Research Assistant to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit. The post holder will work within a programme focused on mitochondrial transport proteins, which are crucial for the functioning of mammalian cells. This project is funded by Apollo Therapeutics and focusses on the development of specific inhibitors of the mitochondrial pyruvate carrier (MPC). MPC has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. The human MPC is a heterodimer of two homologous small membrane proteins, forming two distinct complexes either MPC1/MPC2 or MPC1L/MPC2 [1]. The goal is to develop novel inhibitors of human MPC to treat the aforementioned diseases. Thermostability shift and transport assays have already been developed to screen for better and more specific binders [1]. The...

Ref Number B02-04519 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 12-Feb-2023 About us This is an exciting opportunity to join the group of Franca Fraternali, Professor in Integrative Computational Biology in the Department of Structural and Molecular Biology (https://www.ucl.ac.uk/biosciences/structural-and-molecular-biology) and Director of the ISMB. The Fraternali lab focuses on different aspects and methods in Structural Bioinformatics and Computational Biology/Biophysics, aiming at understanding at a molecular level the nature of the interactions occurring in the cell. The group uses and develops bioinformatics methods to analyse available data on protein structures and...

Ref Number B02-04503 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Fixed-term Working Type On site (> 80% of working time) Available For Secondment No Closing Date 23-Feb-2023 About us UCL is one of the top Universities in the world, with superb facilities for biomedical science and its translation to human disease. The Division of Medicine (http://www.ucl.ac.uk/medicine) has several highly successful groups working in the fields of Immunology and Rheumatology. The work will be primarily carried out at the Centre for Rheumatology in the Rayne Building, which has a state-of-the art flow cytometry suite and access to all facilities needed to complete this programme of work, and the UCL Great Ormond Street Institute for Child Health (UCL GOS ICH) which has strong clinical...

Ref Number B02-04270 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary See advert text Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 15-Feb-2023 About us The King lab is an interdisciplinary lab that seeks to understand the fundamental mechanisms that underpin genome organisation and gene regulation. To this end, we use a combination of single-molecule biophysical techniques, biochemistry and quantitative data analysis. We are especially interested in understanding how changes in DNA architecture and topology drive genomic processes. We are based in the Department of Structural and Molecular Biology at UCL, which is part of the Division of Biosciences (https://www.ucl.ac.uk/biosciences), one of the world’s foremost centres for research and teaching in...

Ref Number B02-03982 Professional Expertise Academic Leadership Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary See advert text Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 13-Feb-2023 About us The Alzheimer's Research UK Drug Discovery Institute at University College London (ARUK UDDI) is a member of the Alzheimer’s Research UK-funded Dementia Discovery Alliance (DDA) - a successful trilogy of institutes (alongside Oxford and Cambridge) translating cutting-edge academic innovations into medicines for patients living with neurodegenerative diseases. Since being established in 2016, the DDA has evaluated over 60 drug targets, set up over 249 strategic collaborations, received over GBP26M in external grants and spun out a biotechnology company. The ARUK UDDI is a fully equipped drug discovery centre...

Applications are invited for a 3-year postdoctoral research position within the Drug Transport and Tumour Metabolism Lab, led by Dr Louise Fets. We are seeking a talented scientist to deliver an exciting and innovative research project funded by a 6-year Cancer Research UK-funded Career Establishment Award on “Understanding how membrane transporters influence variability in cancer drug uptake and investigating implications for efficacy”.... Job listing information Reference MED03624 Date posted 24 January 2023 Closing date 21 February 2023 Job summary Applications are invited for a 3-year postdoctoral research position within the Drug Transport and Tumour Metabolism Lab, led by Dr Louise Fets. We are seeking a talented scientist to deliver an exciting and innovative research project funded by a 6-year Cancer Research UK-funded Career Establishment Award on “Understanding how membrane transporters influence...

Applications are invited for two Senior Research Associates (Junior Group Leaders)) to join The Early Cancer Institute at the University of Cambridge (https://www.earlycancer.cam.ac.uk/), a world-leading centre for research and the UK's only institute dedicated to Early Cancer. The Junior Group Leader(s) will initiate and build an independent research programme related to one or more of the aims (risk prediction, detection, interception) of the Early Cancer Institute. Work related to a cancer of unmet need such as pancreas, or work to augment our emerging interest in immunophenotyping or data science including AI/machine learning is especially encouraged. Applicants should have a PhD in a subject relevant to early detection of cancer with post-doctoral research experience and an excellent academic record and peer-reviewed publications that have had impact in the field. Relevant disciplines include cell and molecular biology, computational biology, physical sciences or other STEM...

The Markowetz lab at the Cancer Research UK Cambridge Institute is looking for a postdoctoral researcher to work on the genomics of chromosomal instability. This is an opportunity for an ambitious scientist to lead the development of computational methods to understand the causes of chromosomal instability and best ways to exploit them, and to closely interact with experimentalists in the lab in an iterative computational-experimental cycle. The project is an extension of the copy number signatures developed in Drews et al, Nature (2022) and funded by an ERC Advanced Grant. The Markowetz lab is a mixed computational/experimental lab with a strong track record in machine learning working on a broad range of topics in cancer genomics and imaging. It offers a supportive and diverse environment (see: Markowetz, 'You are not working for me, I am working with you', PLoS Comp Bio 2015) and has been a jumping board for many successful careers in academia, industry, and spin-out...

We are looking to recruit a highly enthusiastic and motivated full-time Research Assistant to join the group of Prof. Gregory Hannon. The Hannon lab is focused on developing and utilising state-of-the-art genetic tools to help deepen our understanding of cancer enabling new cutting-edge diagnostic and therapeutic approaches to improve outcomes for patients. The successful candidate will support a national interdisciplinary project using CRISPR based approaches to explore what genes are associated with poor responses to radiation therapy, to help identify novel biology and new therapeutic strategies to improve the care for cancer patients. The project forms a key part of the University of Cambridge's Cancer Research UK Radiotherapy Centre of Excellence (RadNet - https://www.cancerresearchuk.org/funding-for-researchers/our-research-infrastructure/radnet-our-radiation-research-network ). The project is in collaboration with the Functional Genomics Centre which is a world...

Fixed-term: The funds for this post are available for 2 years in the first instance. This is an exciting new opportunity for a highly motivated computational researcher to join Professor Sir Shankar Balasubramanian's pioneering research programme to play a key role in advancing the understanding of sequence, structure and chemical modifications in DNA and RNA. Using their expert knowledge of programming languages, statistical/machine learning methods, bioinformatics tools and resources, the ideal candidate will use and develop computational approaches to transform raw sequencing data into biologically meaningful information. The successful candidate will have strong problem analysis/solving skills and be able to work collaboratively within a multidisciplinary team working at the interface between chemistry, biology and bioinformatics. This is a vital post and the applicant will join a small team, with two other bioinformaticians, applying their expertise across the group. The...

The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease. We are looking to appoint a Research Associate to join the laboratory of Dr. Marion MacFarlane to carry out research into the 'Molecular Mechanisms of Cell Death', with a particular focus on obtaining novel insights on the regulation and 3D molecular architecture of key multiprotein signalling complexes that direct cell death/survival. The Lab have pioneered the reconstitution of cell death signalling complexes, e.g. the DISC (doi: 10.1016/j.molcel.2016.02.023) and by intergrating biochemical and structural biology approaches are now focussed on determining the overall 3D architecture of these large macromolecular assemblies and ultimately their structure (doi: 10.1038/s41467-020-20806-9). You will need to hold a PhD in a relevant discipline such as Biochemistry or Structural Biology with...