22 faculty science biochemistry and molecular biology jobs found in London

Ref Number B02-04529 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Fixed-term Working Type On site (> 80% of working time) Available For Secondment No Closing Date 14-Feb-2023 About us The UCL Great Ormond Street Institute of Child Health (GOS ICH) The mission of the UCL GOS Institute of Child Health is to improve the health and well-being of children, and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children’s health research outside North America. GOS ICH’s activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their...

Ref Number B02-04519 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 12-Feb-2023 About us This is an exciting opportunity to join the group of Franca Fraternali, Professor in Integrative Computational Biology in the Department of Structural and Molecular Biology (https://www.ucl.ac.uk/biosciences/structural-and-molecular-biology) and Director of the ISMB. The Fraternali lab focuses on different aspects and methods in Structural Bioinformatics and Computational Biology/Biophysics, aiming at understanding at a molecular level the nature of the interactions occurring in the cell. The group uses and develops bioinformatics methods to analyse available data on protein structures and...

Ref Number B02-04503 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Fixed-term Working Type On site (> 80% of working time) Available For Secondment No Closing Date 23-Feb-2023 About us UCL is one of the top Universities in the world, with superb facilities for biomedical science and its translation to human disease. The Division of Medicine (http://www.ucl.ac.uk/medicine) has several highly successful groups working in the fields of Immunology and Rheumatology. The work will be primarily carried out at the Centre for Rheumatology in the Rayne Building, which has a state-of-the art flow cytometry suite and access to all facilities needed to complete this programme of work, and the UCL Great Ormond Street Institute for Child Health (UCL GOS ICH) which has strong clinical...

Job description Applications are invited for a research assistant to work in the laboratory of Professor Peter Zammit based in the Randall Centre for Cell and Molecular Biophysics within the Faculty of Life Sciences & Medicine. Muscular dystrophies are a group of disorders characterized by progressive skeletal muscle weakness and wasting. Facioscapulohumeral muscular dystrophy (FSHD) is the third most common inherited myopathy. We have identified several pathways that are deregulated in FSHD to cause inefficient muscle repair (Banerji and Zammit (2021). Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7 EMBO Mol Med 2021 Aug 9;13(8):e13695. doi: 10.15252/emmm.202013695). This project will further investigate the role of such pathways in pathology, with an emphasis on those controlling metabolism. Performance of the work will mainly require cell biology, molecular biology, protein analysis skills and bioinformatic skills....

Job description Do you specialize in molecular biology?   Are you interested in immunology, inflammation and cell death? Then this may be the position for you! We are seeking a proficient Research Assistant to join the Tummers lab at the Centre for Inflammation Biology and Cancer Immunology (CIBCI). We ask fundamental questions about how cells live and die, and what this means for our health. We employ multiple omics-based approaches to understand the molecular mechanisms by which cell death drives inflammatory processes.   The successful candidate will have a sophisticated understanding of molecular biology, with demonstrable experience in RNA isolation, RT-qPCR, gene silencing (siRNA and/or CRISPR-Cas9) and overexpression, cytokine/protein detection and cell culture (primary cells and cell lines). You will enjoy working independently, have a proactive and positive attitude and have excellent communication, time management and record keeping...

The laboratory of Prof. David Savage is seeking a research assistant to join an interdisciplinary team researching the links between obesity/ adipose tissue dysfunction and metabolic disease. The group has longstanding interests in rare human inherited disorders of adipose tissue, widely known as lipodystrophies. Remarkably, these diseases are strongly associated with almost identical metabolic disorders as those associated with obesity. Our lab studies humans, as well as using a range of model organisms and cell-based approaches to advance understanding of the mechanistic basis for these associations. The position is funded by the Wellcome Trust and will enable the successful applicant to join an international network using innovative approaches to tackle major challenges in human health. In this position, you will: - keep detailed and accurate records - play a leading role in laboratory management duties such as ordering, stock checks and organising lab inventories. - work...

The laboratory of Professor Susan Ozanne (http://www.mrl.ims.cam.ac.uk/research/principal-investigators/susan-ozanne/) is seeking a postdoctoral research associate who has experience in cardio-metabolic phenotyping in rodent models. Our main research interest is in understanding how obesity and impaired glucose tolerance during pregnancy impacts on offspring cardio-metabolic health. We are particularly interested in establishing intervention strategies in the mother that improve both maternal and offspring cardiovascular and metabolic health. Supported by the British Heart Foundation, this post will involve cardio-metabolic phenotyping of rodent models to study the effects of interventions that target insulin resistance and oxidative stress. Key responsibilities Scientists with experience in cardiovascular and metabolic phenotyping, especially in relation to maternal and fetal physiology, are encouraged to apply. Applicants should have a background in studying...

The research team of Professor Laura Machesky is seeking to recruit a postdoctoral fellow with a background in physics and/or cell biology for a multidisciplinary project. The candidate would join an international team of biologists studying cell migration, mechanosensing and the molecular mechanisms of cancer metastasis. This project is funded by the Human Frontier Scientific Program Organization (HFSPO) and is a part of a joint programme with groups in Japan and USA. Our goal is to build a scanning ion conductance microscope (SICM) and use it to study how cells couple their migration with energetic demands. Cells can adapt their migration machinery for nutrient uptake and perform macropinocytosis during starvation conditions. Little is understood about the properties of macropinocytic structures and new advances in the technology of SICM provide an opportunity to study the structure, mechanical properties and dynamics of this process. Fixed-term: The funds for this post are...

The University of Cambridge wishes to appoint a Research Assistant to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit. The post holder will work within a programme focused on mitochondrial transport proteins, which are crucial for the functioning of mammalian cells. This project is funded by Apollo Therapeutics and focusses on the development of specific inhibitors of the mitochondrial pyruvate carrier (MPC). MPC has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. The human MPC is a heterodimer of two homologous small membrane proteins, forming two distinct complexes either MPC1/MPC2 or MPC1L/MPC2 [1]. The goal is to develop novel inhibitors of human MPC to treat the aforementioned diseases. Thermostability shift and transport assays have already been developed to screen for better and more specific binders [1]. The...

Ref Number B02-04270 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary See advert text Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 15-Feb-2023 About us The King lab is an interdisciplinary lab that seeks to understand the fundamental mechanisms that underpin genome organisation and gene regulation. To this end, we use a combination of single-molecule biophysical techniques, biochemistry and quantitative data analysis. We are especially interested in understanding how changes in DNA architecture and topology drive genomic processes. We are based in the Department of Structural and Molecular Biology at UCL, which is part of the Division of Biosciences (https://www.ucl.ac.uk/biosciences), one of the world’s foremost centres for research and teaching in...

Job description We are seeking for a highly motivated, scientifically curious, and creative postdoctoral research associate with a strong interest mammalian brain development, specifically neuronal ang glial subtype specification to join Setsuko Sahara in collaboration with Laura Andreae's and Eugene Makeyev lab at King’s College London (  https://devneuro.org/cdn/group-overview.php?groupID=87). This 3-year post is funded by the BBSRC.    The Sahara lab studies the mechanisms regulating the self-renewal potential of cortical progenitors and the ability of multipotent cells to differentiate into different types of progenitors and neurons/glia (Ramos et al 2020). The successful applicant will pursue research projects to understand how a vast diversity of cortical projection neurons and glia emerge from a limited number of progenitors during development. We will address this question by interrogating the molecular mechanisms in mouse cortical...

Applications are invited for a Medical Research Council-funded post-doctoral research position to work on the project “Oncogenic signalling cross-talk with intracellular trafficking underpinning early metastatic events” in the Laboratory of Dr Vania Braga. The project will expand our exciting model published hereto investigate the perturbation of cell-cell contacts by oncogenic signalling leading to cell detachment from solid tumours and... Job listing information Reference MED03642 Date posted 25 January 2023 Closing date 22 February 2023 Job summary Applications are invited for a Medical Research Council-funded post-doctoral research position to work on the project “Oncogenic signalling cross-talk with intracellular trafficking underpinning early metastatic events” in the Laboratory of Dr Vania Braga. The project will expand our exciting model published hereto investigate the perturbation of...

We are seeking to recruit a Research Associate to study CAR T cell immune therapies for cancer, using microscopy and other techniques, funded by the pharmaceutical company Bristol Myers Squibb. The project will be based in Prof. Dan Davis’s lab in Imperial College London, South Kensington, to study fundamental aspects of CAR T cell recognition using super-resolution fluorescence microscopy as well as molecular and cell biology techniques.... We are seeking to recruit a Research Associate to study CAR T cell immune therapies for cancer, using microscopy and other techniques, funded by the pharmaceutical company Bristol Myers Squibb. The project will be based in Prof. Dan Davis’s lab in Imperial College London, South Kensington, to study fundamental aspects of CAR T cell recognition using super-resolution fluorescence microscopy as well as molecular and cell biology techniques.... Job listing information Reference NAT01360 Date...

Dr Sarah Marzi invites applications from dynamic, creative, and highly motivated molecular biologists for a postdoctoral Research Associate position to lead on a large-scale MRC project investigating gene regulation in Alzheimer’s disease (https://ukdri.ac.uk/news-and-events/mrc-awards-1-5-million-for-project-examining-genes-in-alzheimers-disease).   With strong molecular biology experience of genomic/ epigenomic approaches, you will use a... Job listing information Reference MED03521 Date posted 5 December 2022 Closing date 4 January 2023 Job summary Dr Sarah Marzi invites applications from dynamic, creative, and highly motivated molecular biologists for a postdoctoral Research Associate position to lead on a large-scale MRC project investigating gene regulation in Alzheimer’s disease (https://ukdri.ac.uk/news-and-events/mrc-awards-1-5-million-for-project-examining-genes-in-alzheimers-disease).  ...

We are seeking a research assistant to work within the Group of Dr. Clémence Blouet at the Institute of Metabolic Science, within a programme aimed at understanding the mechanisms through which central nutrient sensing contributes to metabolic homeostasis. This position offers an ideal opportunity for motivated scientists wishing to develop their research skills in neurobiology within a world-class research environment. In this role, you will undertake laboratory-based work and support research on mouse models. Applicants need to have the ability to perform histological assessments, use various imaging platform and perform image analysis. Applicants also need to have the ability and drive to develop advanced histological and imaging techniques. You will be expected to: - Develop and validate histological, imaging and quantification pipelines - Collect and analyse/process complex data sets, - Ensure the research is carried out in accordance with good practice and in...

Applications are invited for a full-time Research Assistant in the laboratory of Professor Steve Jackson (https://www.stevejacksonlab.org/) based in the internationally renowned Cancer Research UK Cambridge Institute https://www.cruk.cam.ac.uk/, located on the Cambridge Biomedical Campus, Cambridge, UK. The successful candidate will carry out cell and molecular biology work, assisting with on-going projects in the lab to characterise the cell biology and mechanisms of established and new DNA repair pathways and components. Core duties will involve stable cell line generation, knockout cell line generation using CRISPR/Cas9 technology, routine tissue culture, cloning and other molecular work, as well as biochemical studies, including protein purification and mass spectrometry. Other responsibilities will include preparation of reagents, maintenance of lab stocks and assist in the day-to-day running of the laboratory. Preferred skills and experience: Degree or...

The Medical Research Council Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease. We are looking to appoint a Research Associate to join the laboratory of Dr. Marion MacFarlane to carry out research into the 'Molecular Mechanisms of Cell Death', with a particular focus on obtaining novel insights on the regulation and 3D molecular architecture of key multiprotein signalling complexes that direct cell death/survival. The Lab have pioneered the reconstitution of cell death signalling complexes, e.g. the DISC (doi: 10.1016/j.molcel.2016.02.023) and by intergrating biochemical and structural biology approaches are now focussed on determining the overall 3D architecture of these large macromolecular assemblies and ultimately their structure (doi: 10.1038/s41467-020-20806-9). You will need to hold a PhD in a relevant discipline such as Biochemistry or Structural Biology with...

Applications are invited for an enthusiastic and committed post-doctoral scientist to join a vibrant team investigating the cell biology of a group of neurological conditions called hereditary spastic paraplegias. This project is based in the group of Professor Evan Reid at Cambridge Institute for Medical Research and is funded for 3 years. It would be particularly appealing for a cell biologist who is interested in understanding the causes of genetic disease. The project aims to understand the functions of hereditary spastic paraplegia proteins in the molecular pathogenesis of axonal degeneration. The work will be at the interface between cell biology (especially membrane traffic) and molecular neuroscience, and will begin with functional genomic synthetic lethality screens using human iPSC-derived neuronal models of HSP, before going on to characterize the cell biology of "hits" from the screen. The lab employs an integrated approach that combines state of the art cell...

We invite interested graduate scientists to apply for the position of Research Assistant, based at the Crop Science Centre in Cambridge, to work in Professor Uta Paszkowski's laboratory on a research project led by Postdoctoral Research Fellow Dr Sarabeth Buckley. This is an exciting opportunity for somebody passionate about scientific research to gain experience in a state-of-the-art laboratory. The successful candidate will be joining a vibrant and friendly group of research technicians and researchers in the Crop Science Centre. The Centre, which opened in October 2020, benefits from the diverse skills and expertise of the University of Cambridge and NIAB, providing an environment for research excellence in crops with the drive and expertise for scientific translation to address real-world problems. About 50 staff and students are located at the Centre, distributed amongst three established research groups and three fellows starting new research programmes. The...

The University of Cambridge wishes to appoint a Postdoctoral Research Associate to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit. The post holder will work within a programme focused on mitochondrial transport proteins, which are crucial for the functioning of mammalian cells. This project is funded by Apollo Therapeutics and focusses on the development of specific inhibitors of the mitochondrial pyruvate carrier (MPC). MPC has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. The human MPC is a heterodimer of two homologous small membrane proteins, forming two distinct complexes either MPC1/MPC2 or MPC1L/MPC2 [1]. The goal is to develop novel inhibitors of human MPC to treat the aforementioned diseases. Thermostability shift and transport assays have already been developed to screen for better and more specific...