20 faculty science biochemistry and molecular biology jobs found in Cambridge

The laboratory of Professor Susan Ozanne (http://www.mrl.ims.cam.ac.uk/research/principal-investigators/susan-ozanne/) is seeking a postdoctoral research associate who has experience in cardio-metabolic phenotyping in rodent models. Our main research interest is in understanding how obesity and impaired glucose tolerance during pregnancy impacts on offspring cardio-metabolic health. We are particularly interested in establishing intervention strategies in the mother that improve both maternal and offspring cardiovascular and metabolic health. Supported by the British Heart Foundation, this post will involve cardio-metabolic phenotyping of rodent models to study the effects of interventions that target insulin resistance and oxidative stress. Key responsibilities Scientists with experience in cardiovascular and metabolic phenotyping, especially in relation to maternal and fetal physiology, are encouraged to apply. Applicants should have a background in studying...

We are looking for postdoctoral research associate to join the group of Marko Hyvönen (https://hyvonen.bioc.cam.ac.uk) at the Department of Biochemistry on a BBSRC-funded sLOLA project to identify and characterise new plastic degrading enzymes, "plastizymes". The postholder will be part of a multidisciplinary project lead by Professor Florian Hollfelder, with collaborating groups from University of Cambridge, University College London and EMBL's European Bioinformatics Institute. This collaboration aims to find novel plastic-degrading enzymes from metagenomic libraries and use ultrahigh-throughput directed evolution in microdroplets to improve their catalytic properties. The postholder will be in charge of the development of efficient production methods for the new enzymes, for their structural characterisation and for elucidation of interactions of the enzymes with their polymeric substrates using libraries of small molecule substrate analogues. A successful candidate...

The research team of Professor Laura Machesky is seeking to recruit a postdoctoral fellow with a background in physics and/or cell biology for a multidisciplinary project. The candidate would join an international team of biologists studying cell migration, mechanosensing and the molecular mechanisms of cancer metastasis. This project is funded by the Human Frontier Scientific Program Organization (HFSPO) and is a part of a joint programme with groups in Japan and USA. Our goal is to build a scanning ion conductance microscope (SICM) and use it to study how cells couple their migration with energetic demands. Cells can adapt their migration machinery for nutrient uptake and perform macropinocytosis during starvation conditions. Little is understood about the properties of macropinocytic structures and new advances in the technology of SICM provide an opportunity to study the structure, mechanical properties and dynamics of this process. Fixed-term: The funds for this post are...

The University of Cambridge wishes to appoint a Research Assistant to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit. The post holder will work within a programme focused on mitochondrial transport proteins, which are crucial for the functioning of mammalian cells. This project is funded by Apollo Therapeutics and focusses on the development of specific inhibitors of the mitochondrial pyruvate carrier (MPC). MPC has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. The human MPC is a heterodimer of two homologous small membrane proteins, forming two distinct complexes either MPC1/MPC2 or MPC1L/MPC2 [1]. The goal is to develop novel inhibitors of human MPC to treat the aforementioned diseases. Thermostability shift and transport assays have already been developed to screen for better and more specific binders [1]. The...

DEPARTMENT/LOCATION Department of Clinical Biochemistry SALARY £35,858-£63,423 REFERENCE RG34626 CATEGORY Research CLOSING DATE 7 February 2023 We are seeking a Clinical Research Associate wishing to pursue research in the area linking glucose sensor data with insulin pump delivery (closed loop systems) in adults, children and adolescents with type 1 diabetes. The research is funded by the National Institute for Health Research and other funding agencies. Possession of GMC licence to practise is essential. The post would suit a doctor in training at UK FY2 / IMT level or above (or equivalent), wishing to gain experience in clinical and translational research. Postgraduate training in adult endocrinology / diabetes would be desirable for this post, but not essential. Previous experience of clinical research methodology, preferably in the field of diabetes and metabolism would be desirable as would clinical expertise in the use of insulin pumps...

Job description Applications are invited for a research assistant to work in the laboratory of Professor Peter Zammit based in the Randall Centre for Cell and Molecular Biophysics within the Faculty of Life Sciences & Medicine.   Muscular dystrophies are a group of disorders characterized by progressive skeletal muscle weakness and wasting. Facioscapulohumeral muscular dystrophy (FSHD) is the third most common inherited myopathy. We have identified several pathways that are deregulated in FSHD to cause inefficient muscle repair (Banerji and Zammit (2021). Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7 EMBO Mol Med 2021 Aug 9;13(8):e13695. doi: 10.15252/emmm.202013695). This project will further investigate the role of such pathways in pathology, with an emphasis on those controlling metabolism. Performance of the work will mainly require cell biology, molecular biology, protein analysis skills and...

Job description Do you specialize in molecular biology?   Are you interested in immunology, inflammation and cell death? Then this may be the position for you! We are seeking a proficient Research Assistant to join the Tummers lab at the Centre for Inflammation Biology and Cancer Immunology (CIBCI). We ask fundamental questions about how cells live and die, and what this means for our health. We employ multiple omics-based approaches to understand the molecular mechanisms by which cell death drives inflammatory processes.   The successful candidate will have a sophisticated understanding of molecular biology, with demonstrable experience in RNA isolation, RT-qPCR, gene silencing (siRNA and/or CRISPR-Cas9) and overexpression, cytokine/protein detection and cell culture (primary cells and cell lines). You will enjoy working independently, have a proactive and positive attitude and have excellent communication, time management and record keeping...

Ref Number B02-04503 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Fixed-term Working Type On site (> 80% of working time) Available For Secondment No Closing Date 23-Feb-2023 About us UCL is one of the top Universities in the world, with superb facilities for biomedical science and its translation to human disease. The Division of Medicine (http://www.ucl.ac.uk/medicine) has several highly successful groups working in the fields of Immunology and Rheumatology. The work will be primarily carried out at the Centre for Rheumatology in the Rayne Building, which has a state-of-the art flow cytometry suite and access to all facilities needed to complete this programme of work, and the UCL Great Ormond Street Institute for Child Health (UCL GOS ICH) which has strong clinical...

The GEMMA Project GEMMA, which stands for Genome, Environment, Microbiome and Metabolome in Autism, is a multicentre European Commission Project for exploring interactions between gut microbiome, metabolome, epigenome and immune function in order to discover new biomarkers useful for early diagnosis of autism, which would pave the way for early intervention. The European Commission has selected and financed GEMMA project as part of its Horizon... Job listing information Reference MED03611 Date posted 10 January 2023 Closing date 31 January 2023 Job summary The GEMMA Project GEMMA, which stands for Genome, Environment, Microbiome and Metabolome in Autism, is a multicentre European Commission Project for exploring interactions between gut microbiome, metabolome, epigenome and immune function in order to discover new biomarkers useful for early diagnosis of autism, which would pave the way for early intervention. The...

The University of Cambridge wishes to appoint a Postdoctoral Research Associate to join the research group of Prof. Edmund Kunji at the MRC Mitochondrial Biology Unit. The post holder will work within a programme focused on mitochondrial transport proteins, which are crucial for the functioning of mammalian cells. This project is funded by Apollo Therapeutics and focusses on the development of specific inhibitors of the mitochondrial pyruvate carrier (MPC). MPC has emerged as a promising drug target for metabolic disorders, including non-alcoholic steatohepatitis and diabetes, metabolically dependent cancers and neurodegenerative diseases. The human MPC is a heterodimer of two homologous small membrane proteins, forming two distinct complexes either MPC1/MPC2 or MPC1L/MPC2 [1]. The goal is to develop novel inhibitors of human MPC to treat the aforementioned diseases. Thermostability shift and transport assays have already been developed to screen for better and more specific...

The University of Cambridge wishes to appoint a postdoctoral scientist to join the research groups of Prof Maria Grazia Spillantini and Prof Patrick Chinnery at the Department of Clinical Neurosciences and the MRC Mitochondrial Biology Unit https://spillantinilab.medschl.cam.ac.uk/ http://www.mrc-mbu.cam.ac.uk/people/patrick-chinnery. The position is part of a collaborative Wellcome Trust award, lead by Prof Nick Jones (https://www.imperial.ac.uk/people/nick.jones/publications.html ) at the Department of Mathematics at Imperial College, London. The award aims to understand the role of cryptic mitochondrial DNA (mtDNA) mutations in aging and neurodegenerative disease. You will be based at the Clifford Allbutt Building in the Department of Clinical Neurosciences at the University of Cambridge and will have strong links also with Imperial College London, with regular travel between the two sites throughout the tenure. You will be involved in generating and...

Investigating novel therapeutic targets of liver disease in alpha-1 antitrypsin deficiency We are seeking a Research Assistant to join our lab in The Cambridge Institute for Medical Research (CIMR) to study the mechanism of action of exciting new treatment strategies. Applicants are expected to have laboratory experience and a degree in a biological science. Expertise in mammalian cell culture is essential. Experience in proteomics, flow cytometry, CRISPR-Cas9 gene editing, RT-PCR, confocal microscopy and stem cells culture and differentiation would be advantageous, but training will be provided if required. Alpha-1-antitrypsin deficiency is an important monogenic disease affecting over 3.4 million people and is the most common genetic cause of childhood liver disease. The commonest pathogenic mutation of alpha-1 antitrypsin, named the Z allele, is overrepresented in patients requiring liver transplantation for either nonalcoholic steatohepatitis or alcoholic liver...

Job description We are seeking for a highly motivated, scientifically curious, and creative postdoctoral research associate with a strong interest mammalian brain development, specifically neuronal ang glial subtype specification to join Setsuko Sahara in collaboration with Laura Andreae's and Eugene Makeyev lab at King’s College London (  https://devneuro.org/cdn/group-overview.php?groupID=87). This 3-year post is funded by the BBSRC.    The Sahara lab studies the mechanisms regulating the self-renewal potential of cortical progenitors and the ability of multipotent cells to differentiate into different types of progenitors and neurons/glia (Ramos et al 2020). The successful applicant will pursue research projects to understand how a vast diversity of cortical projection neurons and glia emerge from a limited number of progenitors during development. We will address this question by interrogating the molecular mechanisms in mouse cortical...

Ref Number B02-04425 Professional Expertise Teaching, Teaching Support and Examination Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary £47,414 - £55,805 Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 07-Feb-2023 About us Biosciences is one of the world’s foremost centres for research and teaching in the biological sciences and one of the largest Divisions within UCL, undertaking a significant amount of research and teaching. The Division has a diverse portfolio addressing all areas of biology from protein interactions to cell function, organism development, genetics, population studies and the environment. Computational modelling approaches are frequently used alongside experimental research programmes and much of our research crosses traditional boundaries, including the...

Ref Number B02-04270 Professional Expertise Research and Research Support Department School of Life & Medical Sciences (B02) Location London Working Pattern Full time Salary See advert text Contract Type Permanent Working Type On site (> 80% of working time) Available For Secondment No Closing Date 15-Feb-2023 About us The King lab is an interdisciplinary lab that seeks to understand the fundamental mechanisms that underpin genome organisation and gene regulation. To this end, we use a combination of single-molecule biophysical techniques, biochemistry and quantitative data analysis. We are especially interested in understanding how changes in DNA architecture and topology drive genomic processes. We are based in the Department of Structural and Molecular Biology at UCL, which is part of the Division of Biosciences (https://www.ucl.ac.uk/biosciences), one of the world’s foremost centres for research and teaching in...

Dr Sarah Marzi invites applications from dynamic, creative, and highly motivated molecular biologists for a postdoctoral Research Associate position to lead on a large-scale MRC project investigating gene regulation in Alzheimer’s disease (https://ukdri.ac.uk/news-and-events/mrc-awards-1-5-million-for-project-examining-genes-in-alzheimers-disease).   With strong molecular biology experience of genomic/ epigenomic approaches, you will use a... Job listing information Reference MED03521 Date posted 5 December 2022 Closing date 4 January 2023 Job summary Dr Sarah Marzi invites applications from dynamic, creative, and highly motivated molecular biologists for a postdoctoral Research Associate position to lead on a large-scale MRC project investigating gene regulation in Alzheimer’s disease (https://ukdri.ac.uk/news-and-events/mrc-awards-1-5-million-for-project-examining-genes-in-alzheimers-disease).  ...

Applications are invited for a Medical Research Council-funded post-doctoral research position to work on the project “Oncogenic signalling cross-talk with intracellular trafficking underpinning early metastatic events” in the Laboratory of Dr Vania Braga. The project will expand our exciting model published hereto investigate the perturbation of cell-cell contacts by oncogenic signalling leading to cell detachment from solid tumours and... Job listing information Reference MED03642 Date posted 25 January 2023 Closing date 22 February 2023 Job summary Applications are invited for a Medical Research Council-funded post-doctoral research position to work on the project “Oncogenic signalling cross-talk with intracellular trafficking underpinning early metastatic events” in the Laboratory of Dr Vania Braga. The project will expand our exciting model published hereto investigate the perturbation of...

We are seeking to recruit a Research Associate to study CAR T cell immune therapies for cancer, using microscopy and other techniques, funded by the pharmaceutical company Bristol Myers Squibb. The project will be based in Prof. Dan Davis’s lab in Imperial College London, South Kensington, to study fundamental aspects of CAR T cell recognition using super-resolution fluorescence microscopy as well as molecular and cell biology techniques.... We are seeking to recruit a Research Associate to study CAR T cell immune therapies for cancer, using microscopy and other techniques, funded by the pharmaceutical company Bristol Myers Squibb. The project will be based in Prof. Dan Davis’s lab in Imperial College London, South Kensington, to study fundamental aspects of CAR T cell recognition using super-resolution fluorescence microscopy as well as molecular and cell biology techniques.... Job listing information Reference NAT01360 Date...

Applications are invited for an enthusiastic and committed graduate Research Assistant to join a vibrant team investigating the cell biology of a group of neurological conditions called hereditary spastic paraplegias. This project is based in the group of Professor Evan Reid at Cambridge Institute for Medical Research and is funded for 2 years. It would suit a recent biological sciences graduate who would like to obtain more practical laboratory experience before embarking on a PhD. The project aims to understand the functions of hereditary spastic paraplegia proteins in the molecular pathogenesis of axonal degeneration. The work will be at the interface between cell biology (especially membrane traffic) and molecular neuroscience, and will begin with functional genomic synthetic lethality screens using iPSC-derived neuronal models of HSP. The lab employs an integrated approach that combines state of the art cell biology, biochemistry, proteomics, functional genomics and stem...

Ref Number B04-03056 Professional Expertise Research and Research Support Department UCL BEAMS (B04) Location London Working Pattern Full time Salary £38,308- £46,155 Contract Type Fixed-term Working Type On site (> 80% of working time) Available For Secondment No Closing Date 31-Jan-2023 Applications are invited for a Postdoctoral Research Associate position to work on an exciting and ambitious research on biomarker preconcentration in paper-based analytical devices. Point-of-care testing devices enable rapid, affordable, and widely accessible diagnosis, but their limited sensitivity makes them inappropriate for the diagnosis of early-stage diseases. To address this ongoing technological challenge, we aim to introduce a radically new concept for biomarker preconcentration by exploiting colloid transport mechanisms based on interfacial and electrokinetic phenomena. The validation of this new approach could lead to...