28 faculty medicine other medicine jobs found in Edinburgh

The Opportunity: The Wilkinson laboratory seeks a Postdoctoral Research Fellow. This post is available from April 2023 for three years (salary of £35,333-£42,155, dependent upon experience). Selective autophagy of the endoplasmic reticulum (ER-phagy) is emerging as a fundamental pathway in maintenance of cellular health. Furthermore, our laboratory has identified aberrations in ER-phagy during formation and progression of cancer. However, our view of the molecular composition and function(s) of the ER-phagy pathway is incomplete, especially in physiologically relevant settings. We have recently completed a comprehensive integrated proteomic and genetic screen for novel facilitators of ER-phagy. Using cutting-edge cell biological, biochemical and omics techniques, the candidate will uncover the mechanism of action of these molecules and their role in integrating control of ER-phagy with other cellular phenomena such as proteasomal and transcriptional...

The Opportunity: The Wilkinson laboratory seeks a senior research assistant. This Cancer Research UK-funded post is available for a term of three years. Selective autophagy is emerging as a fundamental pathway in maintenance of cellular health. Our laboratory probes the fundamental links between this pathway and cancer progression. Techniques used by the laboratory include both traditional and organoid cell culture, CRISR/Cas9, omic methods and standard molecular biology techniques, coupled with analysis of tissues from murine models of cancer. We currently seek a senior research assistant to provide vital research support to our work in this area. Specifically, the successful applicant will split their time between day-to-day running of the laboratory and working alongside postdoctoral researchers and PhD students to perform lab-bench based experiments. These experiments will contribute to our ongoing research projects. Overall, the work will contribute to a larger,...

The opportunity: This is a unique opportunity to join a team of scientists recognised internationally for work on Mendelian disorders associated with an upregulation of type I interferon signalling; proceeding from clinical definition, through gene identification, to functional characterisation of underlying pathology (see  Nat Rev Immunol 2022;22:471-83  for an overview). We will encourage the development of your research portfolio through involvement in all aspects of the life of the laboratory. Your skills and attributes for success: BSc in Molecular Genetics, Cell Biology or a closely related subject. Laboratory experience, particularly in cell culture, cloning and site-directed mutagenesis. Specific skills relating to all or several of the following techniques: plasma / serum / PBMC preparation, DNA and RNA extraction, PCR, sequencing, RT-PCR, qPCR, western blotting. Ability to apply relevant knowledge, skills and techniques in...

The Opportunity: To join a dynamic and productive team working at the interface between discovery science and translation. Your skills and attributes for success: Experience in cardiovascular or RNA biology. Team player but able to drive your own project. Strong writing skills. Excellent communication skills. Ability to train others. Click here to view a copy of the full job description. As part of this application you are required to submit a document of no more than one page detailing how you meet each of the essential criteria as outlined on the job description. As a valued member of our team you can expect: An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits  pension scheme ,...

The Opportunity: This is an excellent opportunity to be a part of the UK DRI, which will lead the UK’s dementia research effort to deliver a step-change in the scientific understanding of dementias (for more information, see https://ukdri.ac.uk/about-us ). The successful candidate will conduct original research, produce material for publication and dissemination, and work as a member of a research team including training students in research techniques.     Your skills and attributes for success: PhD or other higher level degree (MD/PhD, etc) earned or expected in a relevant discipline (neuroscience, biology, etc). Expertise in relevant experimental approaches and models, analytical techniques and methods. Experience with high resolution imaging and image analysis essential (2-photon, confocal, etc). Ability to communicate complex information clearly, orally and in writing. Click to view a copy of the full  job...

The Opportunity: The post will contribute to an MRC-funded research project investigating the impact of hormones on endometrial function and the establishment of endometriosis. The project will investigate how hormone imbalance alters endometrial function in health and disease. The research approach will combine hormone profiling with validated mouse models that use genetic and pharmacological approaches to manipulate hormone availability. Your skills and attributes for success: A PhD in immunology/cell biology, tissue repair or a related discipline completed or awaiting examination. Expertise in in vivo models of immunology, reproductive biology or tissue repair Expertise in generating and analysing imaging data. Experience in generating and analysing flow cytometric data. Experience of analysing hormone profiling data. Excellent organisational skills and initiative. Click here to view a copy of the full job description. ...

The Opportunity We are looking for a developmental cognitive neuroscientist with a commitment to improving the lives of children and their families through research. You will contribute to behavioural and neuroimaging data collection from infants and 5-year-olds as part of a UKRI MRC-funded programme that aims to discover new strategies for improving outcomes of children born preterm. You will be supported by a team of researchers working together in a programme of research. Your skills and attributes for success: Experience with acquiring and analysing fMRI is essential Experience working with children in the MRI environment is desirable Proficiency in Python, R, Matlab, or another relevant language is essential Expertise in integrated analysis of behavioural and neuroimaging data is desirable Ability to work unsupervised and use own initiative within the multidisciplinary environment and to be an effective communicator within a research team....

The Opportunity: We are delighted to be able to offer up to two Clinical Research PhD Fellowships. The fellow(s) will be funded by the Anne Rowling Regenerative Neurology Clinic on the Rowling Scholars scheme (www.annerowlingclinic.org/careers/rowling-scholars-scheme). This prestigious scholarship offers a salary on a clinical scale while you study towards a PhD on discovery or translation in neurodegenerative disorders. You will conduct an original research project that will be co-designed around your scientific vision, in line with the research strategy of the Anne Rowling Clinic, and focused on multiple sclerosis, motor neuron disease, Parkinson’s and/or dementias including Alzheimer’s disease. You will benefit from the supervision and mentoring of internationally leading clinical and non-clinical investigators. You will produce data for high-quality publications, grant proposals and dissemination to the public, as well as receiving training in...

The Opportunity We aim to understand regulatory mechanisms related to the processing and quality control of RNAs  in vivo , focusing on the Nonsense-mediated decay (NMD) pathway. NMD targets mutated mRNAs harboring premature termination codons (PTCs) for degradation, but also regulates the stability of many cellular transcripts. Importantly, NMD modulates the phenotypic outcome of genetic disorders caused by frameshift or nonsense mutations that generate PTCs. Thus, a better understanding of its regulation  in vivo is needed for designing strategies to modulate the NMD response for therapeutic use. Research objectives We have developed a novel transgenic mouse model harboring an NMD sensor, which will allow to monitor the efficacy, tissue-specificity, and developmental regulation of the NMD response  in vivo , with single-cell resolution. The project will use this mouse model to investigate the complex regulation and...

Applications are invited for the position of Teaching Fellow, to deliver and assess courses on the online Masters programme “Biodiversity, Wildlife and Ecosystem Health” within the Global Health Academy Portfolio delivered in Biomedical Sciences. One 0.8-1.0FTE post is available, fixed until 31st August 2024, although continuation may be possible as the post progresses, depending on student numbers. This role is also advertised as a full-time role (JR 6782). Candidates don't need to apply for both. The Opportunity: Responsibilities include the role of Course Organiser for selected courses, supervision and assessment of dissertation students on the aforementioned programme, student support, contribution to the academic administration of the programme and assisting in course and programme development.  We are particularly interested in candidates who have subject knowledge in the marine environment, conservation genetics and/or animal reproduction but...

Applications are invited for the position of Teaching Fellow, to deliver and assess courses on the online Masters programme “Biodiversity, Wildlife and Ecosystem Health” within the Global Health Academy Portfolio delivered in Biomedical Sciences. One 0.8-1.0FTE post is available, fixed until 31st August 2024, although continuation may be possible as the post progresses, depending on student numbers. This role is also advertised as a part-time role (JR 6785). Candidates don't need to apply for both. The Opportunity: Responsibilities include the role of Course Organiser for selected courses, supervision and assessment of dissertation students on the aforementioned programme, student support, contribution to the academic administration of the programme and assisting in course and programme development.  We are particularly interested in candidates who have subject knowledge in the marine environment, conservation genetics and/or animal reproduction but...

The Opportunity: The Wilkinson laboratory seeks a senior research assistant. This Cancer Research UK-funded post is available for a term of three years. Selective autophagy is emerging as a fundamental pathway in maintenance of cellular health. Our laboratory probes the fundamental links between this pathway and cancer progression. Techniques used by the laboratory include both traditional and organoid cell culture, CRISR/Cas9, omic methods and standard molecular biology techniques, coupled with analysis of tissues from murine models of cancer. We currently seek a senior research assistant to provide vital research support to our work in this area. Specifically, the successful applicant will split their time between day-to-day running of the laboratory and working alongside postdoctoral researchers and PhD students to perform lab-bench based experiments. These experiments will contribute to our ongoing research projects. Overall, the work will contribute to a larger,...

The Opportunity: This post offers an opportunity to carry out evidence synthesis and data visualisation on a major  MRC funded research project working with partners in the US, Mexico, El Salvador and Colombia. The goal of the project is to enhance the delivery of pain relief and palliative care for those least able to access it   Informal enquiries may be directed to Professor Liz Grant, Assistant Principal Global Health Liz.grant@ed.ac.uk. Your skills and attributes for success:  •    Working knowledge and experience of culture, health systems and Universal Health Coverage  in Latin America. •    Skills in health services research or implementation science. •    [Experience in research and project management insert brief bullet point]. •    Ability and experience of working with research investigators  in lower and middle income country settings . ...

The Opportunity:   The Centre for Cardiovascular Science at the Deanery of Clinical Science is looking for an experience individual to contribute to the research, management and publishing relating to a European Research Council Proof-of-Concept grant funded to the Baker lab relating to the activation of a specific genetic locus called CARMN and its role in cardiovascular disease. Your Skills and Attributes for Success :   A PhD (or near completion) or equivalent professional qualification and/or experience in the field of gene regulation/activation, RNA biology or cardiovascular biology/therapy. Ability to communicate complex information clearly, orally and in writing and with appropriate IT and interpersonal skills Experience in relevant approaches and models, analytical techniques and methods (includes practical lab work, data manipulations and subsequent dissemination of research in form of publication), particularly in vivo...

The Opportunity: This project aims to investigate how RNA-mediated large-scale chromatin structure affects transcription and will focus on a role for phase-separated protein/RNA structures. This is a unique opportunity for a recently graduated PhD student or an experienced post-doctoral researcher to join a diverse team of chromatin biologists, physicists and bioinformaticians all investigating chromatin architecture and regulation.   Your skills and attributes for success: PhD in a relevant subject. Strong interest in chromatin biology. Previous experience in FISH and/or super resolution microscopy. Molecular biology and tissue culture techniques including CRISPR, ChIP, RNAi, next generation sequencing. Ability to work independently and as a member of a collaborative team. Click  here  for a copy of the full job description. As a valued member of our team you can expect: An exciting, positive, creative, challenging and...

The Opportunity: Under the guidance of the PI and senior laboratory members of staff, help facilitate a programme of research investigating the cellular and molecular mechanisms regulating liver fibrosis. Your skills and attributes for success: An undergraduate degree in the biological field is required, and significant laboratory experience and knowledge of the research field would be a strong advantage. Applicants must be willing to work in an interdisciplinary environment and develop new skills. Evidence of a strong track-record in some aspect of biology. Evidence of a strong work ethic, independent thinking and ability to work as part of a research team. Interest in the mechanisms underlying liver fibrosis, tissue regeneration and discovery of anti-fibrotic and pro-regenerative therapies. Click to view a copy of the full  job description . As a valued member of our team you can expect: An exciting, positive, creative,...

The Opportunity: To join a dynamic and productive team working at the interface between discovery science and translation. Your skills and attributes for success: Experience in cardiovascular or RNA biology. Team player but able to drive your own project. Strong writing skills. Excellent communication skills. Ability to train others. Click here to view a copy of the full job description. As part of this application you are required to submit a document of no more than one page detailing how you meet each of the essential criteria as outlined on the job description. As a valued member of our team you can expect: An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits  pension scheme ,...

The Opportunity: Responsibilities include the role of Course Organiser for selected courses, supervision and assessment of dissertation students on the aforementioned programme, student support, contribution to the academic administration of the programme and assisting in course and programme development.  We are particularly interested in candidates who have subject knowledge in the marine environment, conservation genetics and/or animal reproduction but welcome applications from anyone with subject knowledge that aligns with our programme course portfolio: DPT: Biodiversity, Wildlife and Ecosystem Health (Online Learning) (MSc) (Part-time) (PTMSCBIOWE1P) (ed.ac.uk) Your skills and attributes for success: The post-holder requires a higher degree and/or experience of teaching in Higher Education in a related discipline, including wildlife conservation, ecology, environmental management/governance, sustainability and the social sciences.   A high...

The Opportunity:   The Centre for Cardiovascular Science at the Deanery of Clinical Science is looking for an experience individual to contribute to the research, management and publishing relating to a European Research Council Proof-of-Concept grant funded to the Baker lab relating to the activation of a specific genetic locus called CARMN and its role in cardiovascular disease. Your Skills and Attributes for Success :   A PhD (or near completion) or equivalent professional qualification and/or experience in the field of gene regulation/activation, RNA biology or cardiovascular biology/therapy. Ability to communicate complex information clearly, orally and in writing and with appropriate IT and interpersonal skills Experience in relevant approaches and models, analytical techniques and methods (includes practical lab work, data manipulations and subsequent dissemination of research in form of publication), particularly in vivo...

The Opportunity: We are seeking to appoint a highly-established researcher to lead an independent research programme seeking to develop pioneering biotechnological interventions in agricultural livestock. We expect the successful candidate to have an internationally-leading research profile, evidenced by substantial success in acquiring independent funding as principal investigator, matched to a strong track record of publishing in high-impact journals. We are particularly interested in candidates who routinely exploit cloning, pluripotent or other stem cells, and/or  in vitro  gametogenesis, and who would benefit from the availability of state-of-the-art technology platforms and large animal facilities at The Roslin Institute including the newly established Large Animal Research and Imaging Facility (LARIF). The position, which would complement existing expertise in the above areas in the Roslin Institute, offers the opportunity to steer the direction of animal...