Yale University
New Haven, CT, USA
Location: New Haven, CT
Open Date: Aug 26, 2022
Deadline: Aug 25, 2023 at 11:59 PM Eastern Time
Description
Context
The recent global stall in the reduction of malaria deaths has made the development of a highly effective vaccine essential. A major challenge to developing an efficacious vaccine is the extensive diversity of Plasmodium falciparum antigens. While genetic diversity plays a major role in immune evasion and is a barrier to the development of both natural and vaccine-induced protective immunity, it has been underprioritized in the evaluation of malaria vaccine candidates. For both current and novel candidates, we will test the role of genetic diversity on immune neutralization by creating transgenic parasites by using efficient CRISPR-Cas9 genome editing. These parasite lines will be used to assess the role of specific variants in immune evasion. This project requires the cohesion of genomic sequencing...