University of Oxford
Oxford Street, London, UK
RDM Investigative Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford
We wish to hire a talented and highly motivated molecular biology postdoc with expertise in protein production, folding and analyses to investigate the translational implications of mechanisms underlying human tissue T cell immune responses funded by the NIHR Biomedical Research Centre. Graham Ogg’s group is studying lipid-specific T cells in the blood and skin in order to define disease pathogenesis and to identify targets for future therapeutic intervention. Samples are taken from well-characterised patients seen by Graham Ogg, as a consultant dermatologist. Lipid-specific and peptide-specific T cells are isolated and analysed through single cell and bulk RNAseq in order to relate clonal T cell populations expressing individual TCR with associated functional responses. The data will be used to characterise responses to novel antigens, as well...